Hironori Hara et al. BTS 2018;3:

Slides:

Advertisements

Similar presentations

Figure 5 ISOX and vorinostat partially restore splicing pattern in DM1 patient-derived fibroblasts. (A) ISOX and vorinostat partially rescue mis-splicing.

Advertisements

TMZ and Ara-C treatment of slice co-cultures.

Innate Regeneration in the Aging Heart: Healing From Within

SERCA2 is a functional adaptor for the alternative toll‐like receptor 9 (TLR9) signalling in cardiomyocytes Co‐immunoprecipitated TLR9 with SERCA2 antibody.

Volume 6, Issue 5, Pages (May 2016)

AβOs bind to and impact hypothalamic neurons Representative immunocytochemistry images of mature hypothalamic neurons in culture exposed to vehicle (Veh)

Volume 3, Issue 6, Pages (December 2014)

Innate Regeneration in the Aging Heart: Healing From Within

Mitofilin cluster distribution is denser in the perinuclear mitochondria. Mitofilin cluster distribution is denser in the perinuclear mitochondria. (A)

Wenyan Du, Kentaro Tamura, Giovanni Stefano, Federica Brandizzi

Isaac Perea-Gil et al. BTS 2016;1:

Fig. 3 BX795 blocks the synthesis of HSV-1 virions.

Fluorescence-stained images and respective bright-field images of mouse spleen tissue sections area investigated using Raman spectroscopy. Fluorescence-stained.

Volume 59, Issue 4, Pages (August 2008)

CCL21 localizes to T cell zone FRCs in young and aged spleens.

CD169+ macrophages play a critical role in mediating innate immune cell reorganization. CD169+ macrophages play a critical role in mediating innate immune.

Selection and Identification of Skeletal-Muscle-Targeted RNA Aptamers

Isaac Perea-Gil et al. BTS 2016;1:

Isaac Perea-Gil et al. BTS 2016;1:

Mitofilin clusters are localized at the horizontal sides of mitochondria. Mitofilin clusters are localized at the horizontal sides of mitochondria. (A.

Smita Srivastava, Patricia S. Grace, Joel D. Ernst Cell Host & Microbe

Detection and tracking of individual SNAP-tagged proteins on the surface of living cells. Detection and tracking of individual SNAP-tagged proteins on.

CD169+ macrophages mediate Lm translocation to the splenic T cell zones. CD169+ macrophages mediate Lm translocation to the splenic T cell zones. (A) Confocal.

Hironori Hara et al. BTS 2018;3:

TrkB-T1 is upregulated in cerebellum of Pex14ΔC/ΔC BL/ICR mouse at P3.

Isabelle Plaisance et al. BTS 2016;j.jacbts

Axonal swelling and impairment of dendritic development in Purkinje cells from Pex14ΔC/ΔC BL/ICR mouse upon treatment with BDNF. Axonal swelling and impairment.

Hironori Hara et al. BTS 2018;3:

BDNF expression in the cerebellum and brain stem region.

Vimentin regulates intracellular trafficking in B cells.

Francis Coffey, Boris Alabyev, Tim Manser Immunity

Isabelle Plaisance et al. BTS 2016;j.jacbts

Sven Y. Surikow et al. BTS 2018;3:

Sven Y. Surikow et al. BTS 2018;3:

Dual-Channel Two-Photon Microscopy Study of Transdermal Transport in Skin Treated with Low-Frequency Ultrasound and a Chemical Enhancer Joseph Kushner,

Altered distribution of γδT IELs in GPR55-deficient mice.

Hironori Hara et al. BTS 2018;3:

Volume 20, Issue 17, Pages (September 2010)

Isaac Perea-Gil et al. BTS 2016;1:

Volume 12, Issue 10, Pages (September 2015)

Hironori Hara et al. BTS 2018;3:

Marc Leushacke, Annie Ng, Joerg Galle, Markus Loeffler, Nick Barker

Defect of cerebellar development and malformation of Purkinje cells in Pex14ΔC/ΔC BL/ICR mice. Defect of cerebellar development and malformation of Purkinje.

ILK knockdown decreases mTOR signaling in PKD kidneys.

Differential secretion profiles of C. elegans TTR models.

Elysse C. Filipe et al. BTS 2018;3:38-53

Imaging intracellular endosymbiont E. coli by fluorescent microscopy.

Haiyang Tang et al. BTS 2018;3:

Occurrence of prominin-1-containing particles in the ventricular fluid of the embryonic mouse brain. Occurrence of prominin-1-containing particles in the.

Changes in fibroblast activation and proliferation outside the wound and CHP staining in the wound bed (related to Fig 5)‏ Changes in fibroblast activation.

PD-L1 expression is maintained on NCMs under inflammatory conditions and PD-L1+NCMs are found in TLOs. PD-L1 expression is maintained on NCMs under inflammatory.

MET activation increases the density of Syn-GFP/bassoon and Syn-GFP/PSD-95 clusters in neocortical neurons. MET activation increases the density of Syn-GFP/bassoon.

CD169+ macrophages mediate the transport of bacteria to T cell zones by trans-infecting CD8α+ DCs. CD169+ macrophages mediate the transport of bacteria.

Pie charts (for all the mice together) and bar graph (for individual mouse) showing relative percentage of T cells and B cells present in the Raman spectroscopy–investigated.

ChREBPα increases β-cell mitochondrial activity and ATP production in human islets. ChREBPα increases β-cell mitochondrial activity and ATP production.

Oxidative stress is elevated in tumors grown in Fbln5−/− mice.

Temporal origins of h-ChCs labeled in Cdh6-CreER;Dlx5/6-Flp;Ai65 mice.

c-Fos in RFMes GABAergic neurons across groups.

Effect of M-cadherin RNAi on apoptosis in confluent C2C12 myoblasts.

Detection and classification of dendritic spines in transfected hippocampal neurons. Detection and classification of dendritic spines in transfected hippocampal.

Subcellular distribution of Mst4 and aPKCι in in vivo enterocytes.

Domain 3, comprising the basolateral calyx and the stretch of axon leading to the heminode, selectively expressed NaV channels, KCNQ3, and certain scaffolding.

Fig. 2. Immunocytochemical localization of NPC1 in alveolar type II cells. Isolated rat alveolar type II cells were fixed after 24 h in culture, double-labeled.

GABAARs in RFMes GABAergic neurons across groups.

Brain ischemic tolerance model using mouse MCAO

Relative Protein Quantification of CcmK4, RbcS, and CcmM in the Carboxysome under Different CO2 Levels and Light Intensities using Confocal Microscopy.

Selective delivery of pIC/PPHAffibody decreases the survival of HER2-overexpressing cells. Selective delivery of pIC/PPHAffibody decreases the survival.

Michael A. Makara et al. BTS 2018;3:

Fig. 1 Deficient CD73 and CD39 expressions and extracellular adenosine concentration in BM of OVX animals. Deficient CD73 and CD39 expressions and extracellular.

The neuropod cells. The neuropod cells. (Top left) Neuropod cells synapse with sensory neurons in the small intestine, as shown in a confocal microscopy.

Presentation transcript:

Hironori Hara et al. BTS 2018;3:639-653 TT-10 Enhances Proliferation of Existing CMs, and Decreases ROS and DNA Damage After MI (A) The percentage of mOrange-labeled clustered CMs in αMHC-MerCreMer; Rosa26rbw/+ mice. The increase from the background (MI [−]) indicates the proliferation of existing CMs (clonal expansion). Representative images of infarct border-zone myocardium are shown. Inset images were enlarged by confocal microscopy. Arrowheads indicate positive CMs; white asterisk indicates infarct area. n = 6 (MI [−]), 7 (vehicle), and 6 (TT-10). Scale bars: 100 μm; 25 μm in inset. (B) The relative mean fluorescence intensity for measuring ROS generation, detected by a mainly nuclear localized ROS-sensitive CellROX Green probe. Mean fluorescence intensity in the infarct border-zone myocardium relative to that in MI [−] mouse myocardium was shown. Representative images of infarct border-zone are shown. White asterisk indicates infarct area. n = 7 (MI [−]), 7 (vehicle), and 8 (TT-10). Scale bars: 100 μm; 50 μm in inset. (C) Quantitative analyses of γH2AX-positive CMs in the infarct border-zone 1 week after MI, with representative images. Arrowheads indicate positive CMs; white asterisk indicates infarct area. n = 10 (vehicle), and 12 (TT-10). Scale bars: 50 μm; 25 μm in inset. *p < 0.05, **p < 0.01 versus vehicle control. ##p < 0.01, ###p < 0.001 versus non-MI baseline. Abbreviations as in Figures 1, 4, and 5. Hironori Hara et al. BTS 2018;3:639-653 2018 The Authors