Volume 4, Issue 5, Pages (May 2017)

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Volume 4, Issue 5, Pages 365-377 (May 2017) Ketamine augmentation of electroconvulsive therapy to improve neuropsychological and clinical outcomes in depression (Ketamine-ECT): a multicentre, double-blind, randomised, parallel-group, superiority trial Prof Ian M Anderson, MD, Prof Andrew Blamire, PhD, Tim Branton, MBBS, Ross Clark, MBChB, Darragh Downey, PhD, Prof Graham Dunn, PhD, Andrew Easton, MMedSc, Prof Rebecca Elliott, PhD, Prof Clare Elwell, PhD, Katherine Hayden, MBChB, Fiona Holland, MSc, Salman Karim, MD, Prof Colleen Loo, MD, Jo Lowe, Rajesh Nair, MBBS, Timothy Oakley, MBChB, Antony Prakash, MBBS, Parveen K Sharma, MD, Prof Stephen R Williams, DPhil, R Hamish McAllister-Williams, MD Claire Blakeley, Katherine Crosby, Aisha Perkis, Graham Spencer, Liam Trevithick, Amanda Watson, Francesca Williams, Audrey Williamson Prof Ian M Anderson, MD, Prof Andrew Blamire, PhD, Tim Branton, MBBS, Ross Clark, MBChB, Darragh Downey, PhD, Prof Graham Dunn, PhD, Andrew Easton, MMedSc, Prof Rebecca Elliott, PhD, Prof Clare Elwell, PhD, Katherine Hayden, MBChB, Fiona Holland, MSc, Salman Karim, MD, Prof Colleen Loo, MD, Jo Lowe, Rajesh Nair, MBBS, Timothy Oakley, MBChB, Antony Prakash, MBBS, Parveen K Sharma, MD, Prof Stephen R Williams, DPhil, R Hamish McAllister-Williams, MD Claire Blakeley, Katherine Crosby, Aisha Perkis, Graham Spencer, Liam Trevithick, Amanda Watson, Francesca Williams, Audrey Williamson The Lancet Psychiatry Volume 4, Issue 5, Pages 365-377 (May 2017) DOI: 10.1016/S2215-0366(17)30077-9 Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license Terms and Conditions

Figure Trial profile *Modified intention-to-treat was defined as all patients randomised to treatment who received a first ECT. Analysis required one or more valid postbaseline assessments: numbers analysed were 32–33 in the ketamine group and 35–36 in the saline group depending on outcome measure. The Lancet Psychiatry 2017 4, 365-377DOI: (10.1016/S2215-0366(17)30077-9) Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license Terms and Conditions