Overview of the complex interactions among molecular classifications of TNBC based on genomic, transcriptomic, proteomic, epigenomic, and immune characterization.

Slides:

Advertisements

Similar presentations

 2013 Genentech USA, Inc. All rights reserved. Disclosure/Disclaimer The Molecular Basis of Gliomas slide presentation is not an independent educational.

Advertisements

Comparison of Mutations and Protein Expression in Potentially Actionable Targets in 5500 Triple Negative vs. non-Triple Negative Breast Cancers Joyce A.

MSH2 and Human Nonpolyposis Colon Cancer Yael Aschner.

HNPCC and MLH1 Qi Peng Cancer Biology March 30 th, 2006.

Cell Signaling Lecture 10. Receptor Tyrosine Kinases Regulate cell proliferation, differentiation, cell survival and cellular metabolism The signaling.

FUNCTIONAL GENOMICS REVEAL THAT THE SERINE SYNTHESIS PATHWAY IS ESSENTIAL IN BREAST CANCER Introduction: Tim Butler Spellman Lab.

Bonny Blackard Biology 169 April 4, 2006

Chapter 24: Gonadal Steroids Katrien Venken, Steven Boonen, Roger Bouillon, and Dirk Vanderschueren.

Table S1: The results of ER, PgR, and HER2 status in IHC testing and mRNA expression in the full Consortium population (N=389) HER2 statusER status PgR.

Samsung Genome Institute Samsung Medical Center

Natural History, Response to Treatment

Figure 1. Correlation between estrogen receptor (ER), progesterone receptor (PR), and Ki-67 expression in primary breast tumors and synchronous axillary.

Figure 1 The heterogenous landscape of triple-negative breast cancer

Volume 389, Issue 10087, Pages (June 2017)

Genetics In Breast Cancer

Targeted Next-Generation Sequencing for Hereditary Cancer Syndromes

Mismatch Repair Processing of Iododeoxyuridine

Inhibitor of MAP kinase activation blocks colon cancer growth

Felix Dietlein, Lisa Thelen, H. Christian Reinhardt Trends in Genetics

Figure 1 Treatment-induced resistance and evolution to lineage crisis

Gene Expression Profiling of Large Cell Lung Cancer Links Transcriptional Phenotypes to the New Histological WHO 2015 Classification Anna Karlsson, MSc,

Origin of Chromosomal Translocations in Lymphoid Cancer

Diagnostic approaches to measure the impact of cancer therapies on clonal evolution. Diagnostic approaches to measure the impact of cancer therapies on.

Copy-number alterations in an archival breast cancer sample.

IHC staining of FFPE esophageal tissues in tissue microarrays (×20).

Uncovering a Tumor Suppressor for Triple-Negative Breast Cancers

Volume 172, Issue 1, Pages (January 2018)

Tumor intrinsic subtype is reflected in cancer-adjacent tissue.

Gene Expression Profiling of Large Cell Lung Cancer Links Transcriptional Phenotypes to the New Histological WHO 2015 Classification Anna Karlsson, MSc,

Volume 148, Issue 1, Pages (January 2018)

Invasion front (pushing margin) of the patient's tumour from the primary resection showing a high number of tumour-infiltrating leucocytes, which is characteristic.

Mismatch repair immunohistochemistry (MMR IHC).

Characterizing the Killer Colorectal Carcinomas

Distribution of intrinsic subtypes among TNBC and distribution of TNBC among basal-like breast cancer. Distribution of intrinsic subtypes among TNBC and.

Figure 5 Systems biological model of IBS

Illustration of matched (FL-IFN-γR2/GFP and IFN-γR1/EBFP) and mismatched (IFN-γR1/EBFP and FL-IL-10R2/GFP) pairs of receptors. Illustration of matched.

Transcriptomic and proteomic data sets available in the Listeriomics database. Transcriptomic and proteomic data sets available in the Listeriomics database.

Nat. Rev. Urol. doi: /nrurol

Volume 152, Issue 1, Pages (January 2019)

IHC staining of various cystic structures

Altered pathways in prostate cancer.

Genetic landscape of salivary duct carcinoma.

Bar plot representation of the transcriptomic changes in Δsaci_ptp and Δsaci_pp2a. Bar plot representation of the transcriptomic changes in Δsaci_ptp and.

Classification of the 1458 identified proteins into molecular functions. Classification of the 1458 identified proteins into molecular functions. The pie.

Fibroid growth and medical options for treatment

Distribution of immune checkpoint in tumor cells and immune microenvironment. CTLA-4, cytotoxic T lymphocyte antigen-4; MHC, major histocompatibility complex;

Signalling pathways and involved entities that are unravelling experimental therapeutic targets for TNBC. Depicted molecular landscape of TNBC confers.

Protein expression profile in a dasatinib-resistant cell line.

A, Proportion of variants detected in the MMR genes.

Targetable alterations and pathways in TNBCs after NAC

Induction of apoptosis in mismatch repair-deficient tumor cell lines after microinjection of phMSH2 and phMLH1 cDNA expression constructs. Induction of.

Illustration of cancer cells and tumor microenvironment–deregulated miRNA target networks leading to tumor growth and progression. Illustration of cancer.

HGSOC mutational processes are established early and are patient-specific. HGSOC mutational processes are established early and are patient-specific. A,

Clustering analysis of DTC-associated genes.

Possible outcomes of therapeutic treatments using the spiral model.

Human cancer immunotherapy strategies targeting B7-H3 A, blockade of B7-H3 with blocking mAbs neutralizes inhibitory signaling in its unidentified receptor(s)

Frequently mutated genes in colorectal cancer.

A, Proportion for different in silico predictions at the RNA level.

Anti–PD-1/PD-L1–mediated acquired resistance is dependent on CD38-generated adenosine in the tumor microenvironment. Anti–PD-1/PD-L1–mediated acquired.

Cabozantinib causes significant tumor cell elimination in vivo, but modest apoptosis induction in vitro. Cabozantinib causes significant tumor cell elimination.

An isogenic cell line screen reveals genomic drivers of drug response.

Compartmentalized cellular functions of KDM4A.

MYC and LYN are coexpressed and have interdependent clinical outcomes.

PTEN genotype frequently dictates PTEN expression status, but evidence of heterogeneous staining implies polyclonality within some ovarian tumors. PTEN.

High genomic fidelity of SCLC PDX models derived from both CTCs and biopsies. High genomic fidelity of SCLC PDX models derived from both CTCs and biopsies.

Genomic and proteomic profiling of ovarian cancer cell lines.

STK11/LKB1 genetic alterations are associated with shorter progression-free and overall survival with PD-1 blockade among KRAS-mutant LUAC in the SU2C.

IHC staining of FFPE esophageal tissues in tissue microarrays (×20).

Tackling Resistance to PI3K Inhibition by Targeting the Epigenome

Model of the change in receptor structure on engagement of the ligand IFN-γ. Model of the change in receptor structure on engagement of the ligand IFN-γ.

Presentation transcript:

Overview of the complex interactions among molecular classifications of TNBC based on genomic, transcriptomic, proteomic, epigenomic, and immune characterization of the tumor and its microenvironment. Overview of the complex interactions among molecular classifications of TNBC based on genomic, transcriptomic, proteomic, epigenomic, and immune characterization of the tumor and its microenvironment. ER, estrogen receptor; PR, progesterone receptor; Mut, mutant; RTK, receptor tyrosine kinase; MMR, mismatch repair; CNA, copy-number alteration; AR, androgen receptor; HRD, homologous recombination deficiency; IHC, immunohistochemistry. Ana C. Garrido-Castro et al. Cancer Discov 2019;9:176-198 ©2019 by American Association for Cancer Research