Revisiting the Function of CDK7 in Transcription by Virtue of a Recently Described TFIIH Kinase Inhibitor Frédéric Coin, Jean-Marc Egly Molecular Cell

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Revisiting the Function of CDK7 in Transcription by Virtue of a Recently Described TFIIH Kinase Inhibitor Frédéric Coin, Jean-Marc Egly Molecular Cell Volume 59, Issue 4, Pages 513-514 (August 2015) DOI: 10.1016/j.molcel.2015.08.006 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Pol II Initiation, Pausing, and Release Recruitment of Pol II by GTFs results in the formation of the PIC. After phosphorylation of the serine 5 of the CTD (pS5) by CDK7, Pol II enters into pause 30–50 nt downstream from the transcription start site (+1). Pol II pausing occurs through the recruitment of DSIF and NELF and is facilitated by the +1 nucleosome. CDK9, as part of P-TEFb, mediates the release of paused Pol II by the phosphorylation of DSIF, NELF, and the serine 2 of the CTD (pS2). Phosphorylation of NELF induces its release from Pol II. Phosphorylated DSIF stays associated with elongating Pol II. Molecular Cell 2015 59, 513-514DOI: (10.1016/j.molcel.2015.08.006) Copyright © 2015 Elsevier Inc. Terms and Conditions