Effect of intranasal azelastine and beclomethasone dipropionate on nasal symptoms, nasal cytology, and bronchial responsiveness to methacholine in allergic.

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Presentation transcript:

Effect of intranasal azelastine and beclomethasone dipropionate on nasal symptoms, nasal cytology, and bronchial responsiveness to methacholine in allergic rhinitis in response to grass pollens Andrea Pelucchi, MD, Anita Chiapparino, BSc, Berardino Mastropasqua, MD, Luigi Marazzini, MD, Alicia Hernandez, BSc, Antonio Foresi, MD Journal of Allergy and Clinical Immunology Volume 95, Issue 2, Pages 515-523 (February 1995) DOI: 10.1016/S0091-6749(95)70313-6 Copyright © 1995 Mosby, Inc. Terms and Conditions

FIG. 1 Mean weekly symptom scores for each treatment group and mean weekly grass pollen counts during 5 weeks of study. Line represents mean weekly pollen count. *p < 0.05 compared with placebo group. gr/m3, Grains per cubic meter. Journal of Allergy and Clinical Immunology 1995 95, 515-523DOI: (10.1016/S0091-6749(95)70313-6) Copyright © 1995 Mosby, Inc. Terms and Conditions

FIG. 2 Mean weekly antihistamine tablets for each treatment group during 5 weeks of study. *p < 0.05 compared with placebo group. Journal of Allergy and Clinical Immunology 1995 95, 515-523DOI: (10.1016/S0091-6749(95)70313-6) Copyright © 1995 Mosby, Inc. Terms and Conditions

FIG. 3 Mean number of neutrophils and eosinophils in nasal lavage obtained during the grass pollen season in each treatment group. *p < 0.05 compared with placebo group. Journal of Allergy and Clinical Immunology 1995 95, 515-523DOI: (10.1016/S0091-6749(95)70313-6) Copyright © 1995 Mosby, Inc. Terms and Conditions

FIG. 4 Individual values of methacholine PD 20, expressed as micromoles, at baseline and during the grass pollen season in each treatment group. **p < 0.015 compared with baseline. Journal of Allergy and Clinical Immunology 1995 95, 515-523DOI: (10.1016/S0091-6749(95)70313-6) Copyright © 1995 Mosby, Inc. Terms and Conditions

FIG. 4 Individual values of methacholine PD 20, expressed as micromoles, at baseline and during the grass pollen season in each treatment group. **p < 0.015 compared with baseline. Journal of Allergy and Clinical Immunology 1995 95, 515-523DOI: (10.1016/S0091-6749(95)70313-6) Copyright © 1995 Mosby, Inc. Terms and Conditions

FIG. 4 Individual values of methacholine PD 20, expressed as micromoles, at baseline and during the grass pollen season in each treatment group. **p < 0.015 compared with baseline. Journal of Allergy and Clinical Immunology 1995 95, 515-523DOI: (10.1016/S0091-6749(95)70313-6) Copyright © 1995 Mosby, Inc. Terms and Conditions