Volume 9, Issue 1, Pages 49-56 (January 2012) Trigger-specific ion-channel mechanisms, risk factors, and response to therapy in type 1 long QT syndrome  Ilan Goldenberg, MD, Princy Thottathil, MD, Coeli M. Lopes, PhD, Arthur J. Moss, MD, Scott McNitt, MS, Jin O-Uchi, MD, PhD, Jennifer L. Robinson, MS, Wojciech Zareba, MD, PhD, Michael J. Ackerman, MD, Elizabeth S. Kaufman, MD, Jeffrey A. Towbin, MD, Michael Vincent, MD, Alon Barsheshet, MD  Heart Rhythm  Volume 9, Issue 1, Pages 49-56 (January 2012) DOI: 10.1016/j.hrthm.2011.08.020 Copyright © 2012 Heart Rhythm Society Terms and Conditions

Figure 1 Gender and trigger-specific risk for cardiac events in LQT1. Kaplan–Meier cumulative probability of (A) exercise-triggered events, (B) arousal-triggered events, and (C) sleep/rest-triggered events by gender. LQT1 = long-QT syndrome type 1. Heart Rhythm 2012 9, 49-56DOI: (10.1016/j.hrthm.2011.08.020) Copyright © 2012 Heart Rhythm Society Terms and Conditions

Figure 2 Mutation location and trigger-specific risk for cardiac events in LQT1. Kaplan–Meier cumulative probability of (A) exercise-triggered events, (B) arousal-triggered events, and (C) sleep/rest-triggered events by mutation location and type. C/N = C/N terminus; C-loops = cytoplasmic loops; LQT1 = long-QT syndrome type 1. Heart Rhythm 2012 9, 49-56DOI: (10.1016/j.hrthm.2011.08.020) Copyright © 2012 Heart Rhythm Society Terms and Conditions

Figure 3 Cumulative probability of trigger-specific first and recurrent cardiac events in LQT1. Kaplan–Meier cumulative probabilities of first and recurrent cardiac events of the same type: exercise-triggered events (A), arousal-triggered events (B), and sleep/rest-triggered events (C). For the assessment of the rate of recurrent events, follow-up is restarted at the time for the first event. LQT1 = long-QT syndrome type 1. Heart Rhythm 2012 9, 49-56DOI: (10.1016/j.hrthm.2011.08.020) Copyright © 2012 Heart Rhythm Society Terms and Conditions