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Volume 6, Issue 7, Pages (July 2009)

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1 Volume 6, Issue 7, Pages 984-992 (July 2009)
Arrhythmogenic right ventricular cardiomyopathy/dysplasia clinical presentation and diagnostic evaluation: Results from the North American Multidisciplinary Study  Frank I. Marcus, MD, Wojciech Zareba, MD, Hugh Calkins, MD, Jeffrey A. Towbin, MD, Cristina Basso, MD, David A. Bluemke, MD, PhD, N.A. Mark Estes, MD, Michael H. Picard, MD, Danita Sanborn, MD, Gaetano Thiene, MD, Thomas Wichter, MD, David Cannom, MD, David J. Wilber, MD, Melvin Scheinman, MD, Henry Duff, MD, James Daubert, MD, Mario Talajic, MD, Andrew Krahn, MD, Michael Sweeney, MD, Hasan Garan, MD, Scott Sakaguchi, MD, Bruce B. Lerman, MD, Charles Kerr, MD, Jack Kron, MD, Jonathan S. Steinberg, MD, Duane Sherrill, PhD, Kathleen Gear, RN, Mary Brown, MS, Patricia Severski, BS, Slava Polonsky, MS, Scott McNitt, MS  Heart Rhythm  Volume 6, Issue 7, Pages (July 2009) DOI: /j.hrthm Copyright © 2009 Heart Rhythm Society Terms and Conditions

2 Figure 1 Sequence of evaluation of patients suspected of having arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D). PI = principal investigator. Heart Rhythm 2009 6, DOI: ( /j.hrthm ) Copyright © 2009 Heart Rhythm Society Terms and Conditions

3 Figure 2 A: Relationship between initial classification of patients as affected at enrollment and final classification based on task force criteria after core laboratory analysis of diagnostic tests. B: Relationship of initial classification of patients as borderline at enrollment and final classification based on task force criteria after core laboratory analysis of diagnostic tests. Heart Rhythm 2009 6, DOI: ( /j.hrthm ) Copyright © 2009 Heart Rhythm Society Terms and Conditions

4 Figure 3 Percentage of the individual tests evaluated by the core laboratories as affected in 73 arrhythmogenic right ventricular cardiomyopathy/dysplasia affected probands and 28 borderline probands. ECG = electrocardiogram; MRI = magnetic resonance imaging; SAECG = signal-averaged electrocardiogram. Heart Rhythm 2009 6, DOI: ( /j.hrthm ) Copyright © 2009 Heart Rhythm Society Terms and Conditions

5 Figure 4 Decline in C statistic for each test removed individually from a combined seven-test model predicting the final phenotype of affected arrhythmogenic right ventricular cardiomyopathy/dysplasia. The largest decrease of diagnostic accuracy of this multivariant model is observed after removing the echocardiogram; the least decline is observed when removing the magnetic resonance imaging (MRI). ECG = electrocardiogram; SAECG = signal-averaged electrocardiogram. Heart Rhythm 2009 6, DOI: ( /j.hrthm ) Copyright © 2009 Heart Rhythm Society Terms and Conditions


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