Jyotsna Pundir, Sesh Kamal Sunkara, Tarek El-Toukhy, Yacoub Khalaf

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Presentation transcript:

Meta-analysis of GnRH antagonist protocols: do they reduce the risk of OHSS in PCOS? Jyotsna Pundir, Sesh Kamal Sunkara, Tarek El-Toukhy, Yacoub Khalaf Reproductive BioMedicine Online Volume 24, Issue 1, Pages 6-22 (January 2012) DOI: 10.1016/j.rbmo.2011.09.017 Copyright © 2011 Reproductive Healthcare Ltd. Terms and Conditions

Figure 1 Study selection process for the systematic review of GnRH antagonist versus GnRH long agonist protocols in ovarian stimulation in patients with polycystic ovary syndrome undergoing IVF/intracytoplasmic sperm injection. Reproductive BioMedicine Online 2012 24, 6-22DOI: (10.1016/j.rbmo.2011.09.017) Copyright © 2011 Reproductive Healthcare Ltd. Terms and Conditions

Figure 2 Ovarian hyperstimulation syndrome (OHSS)-related outcomes of GnRH antagonist versus GnRH long agonist protocols, per woman. (A–E) OHSS rates: (A) Mild OHSS; (B) Moderate OHSS; (C) Severe OHSS; (D) Moderate and severe OHSS; (E) Moderate, moderate and severe, and severe OHSS. (F) Cycle cancellation rate per women. Reproductive BioMedicine Online 2012 24, 6-22DOI: (10.1016/j.rbmo.2011.09.017) Copyright © 2011 Reproductive Healthcare Ltd. Terms and Conditions

Figure 3 Gonadotrophin-related outcomes of GnRH antagonist versus GnRH long agonist protocols, per woman. (A) Total duration of gonadotrophin stimulation. (B) Total dose of gonadotrophin. Reproductive BioMedicine Online 2012 24, 6-22DOI: (10.1016/j.rbmo.2011.09.017) Copyright © 2011 Reproductive Healthcare Ltd. Terms and Conditions

Figure 4 Ovarian stimulation-related outcomes of GnRH antagonist versus GnRH long agonist protocols, per woman. (A) Oestradiol concentration on day of ovulation trigger. (B) Number of oocytes retrieved. Reproductive BioMedicine Online 2012 24, 6-22DOI: (10.1016/j.rbmo.2011.09.017) Copyright © 2011 Reproductive Healthcare Ltd. Terms and Conditions

Figure 5 Pregnancy and miscarriage rates for GnRH antagonist versus GnRH long agonist protocols, per woman. (A) Clinical pregnancy rate. (B) Miscarriage rate. Reproductive BioMedicine Online 2012 24, 6-22DOI: (10.1016/j.rbmo.2011.09.017) Copyright © 2011 Reproductive Healthcare Ltd. Terms and Conditions