Inhaled Antibiotics for Patients With CF in the Era of CFTR Modulators

Program Overview

Treatment Goals in CF

Prevalence of Pulmonary Infection in Children and Adolescents With CF

Prevalence of Pulmonary Infection in Adults With CF

Emerging Infections in CF

CFTR Dysfunction, Chronic Infection, and Disease Progression

Targeting the Airway Microenvironment With Inhaled Antibiotics

Managing Chronic P aeruginosa Infection

Considerations in Managing Chronic P aeruginosa Infection in Children

Pulmonary Exacerbations

Delivery of Inhaled Antibiotics

Challenges of Eradicating P aeruginosa in Children

Inhaled Antibiotics Targeting P aeruginosa

Inhaled Antibiotic Therapy: Guideline Recommendations

Continuous Alternating Therapy: Rationale

CAT Study: Design

CAT Study: Results

Using CAT in Clinical Practice

Maximizing Delivery of Inhaled Antibiotics

Predictors of Adherence to Inhaled Antibiotics

Rates of Adherence to CF Therapies

Effects of Therapy Adherence on Exacerbations

Using Inhaled Antibiotics Alongside CFTR Modulators

Potential Impact of CFTR Modulators on the Microbiome

Conclusions

Abbreviations

Abbreviations (cont)