TTBK2 Kinase: Linking Primary Cilia and Cerebellar Ataxias

Slides:

Advertisements

Similar presentations

Aurora Kinases and Protein Phosphatase 1 Mediate Chromosome Congression through Regulation of CENP-E Yumi Kim, Andrew J. Holland, Weijie Lan, Don W. Cleveland.

Advertisements

SOD1 Integrates Signals from Oxygen and Glucose to Repress Respiration Amit R. Reddi, Valeria C. Culotta Cell Volume 152, Issue 1, Pages (January.

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.

The RAG Recombinase Dictates Functional Heterogeneity and Cellular Fitness in Natural Killer Cells Jenny M. Karo, David G. Schatz, Joseph C. Sun Cell Volume.

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity Jenni Durieux, Suzanne Wolff, Andrew Dillin Cell Volume 144, Issue 1, Pages.

Bleach Activates a Redox-Regulated Chaperone by Oxidative Protein Unfolding J. Winter, M. Ilbert, P.C.F. Graf, D. Özcelik, U. Jakob Cell Volume 135, Issue.

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell

Making Proteins in the Powerhouse B. Martin Hällberg, Nils-Göran Larsson Cell Metabolism Volume 20, Issue 2, Pages (August 2014) DOI: /j.cmet

Common Sense about Taste: From Mammals to Insects David A. Yarmolinsky, Charles S. Zuker, Nicholas J.P. Ryba Cell Volume 139, Issue 2, Pages (October.

UvrD Helicase Unwinds DNA One Base Pair at a Time by a Two-Part Power Stroke Jae Young Lee, Wei Yang Cell Volume 127, Issue 7, Pages (December.

Nucleation and Transport Organize Microtubules in Metaphase Spindles Jan Brugués, Valeria Nuzzo, Eric Mazur, Daniel J. Needleman Cell Volume 149, Issue.

Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell

Xenobiotics Shape the Physiology and Gene Expression of the Active Human Gut Microbiome Corinne Ferrier Maurice, Henry Joseph Haiser, Peter James Turnbaugh.

Cancer Metabolism Cell Volume 148, Issue 3, (February 2012) DOI: /j.cell Copyright © 2012 Terms and Conditions Terms and Conditions.

The Monarch Butterfly Genome Yields Insights into Long-Distance Migration Shuai Zhan, Christine Merlin, Jeffrey L. Boore, Steven M. Reppert Cell Volume.

Dynein Anchors Its mRNA Cargo after Apical Transport in the Drosophila Blastoderm Embryo Renald Delanoue, Ilan Davis Cell Volume 122, Issue 1, Pages

Encoding of Both Analog- and Digital-like Behavioral Outputs by One C. elegans Interneuron Zhaoyu Li, Jie Liu, Maohua Zheng, X.Z. Shawn Xu Cell Volume.

Nuclear Receptors, RXR, and the Big Bang Ronald M. Evans, David J. Mangelsdorf Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell

Transmembrane Receptor DCC Associates with Protein Synthesis Machinery and Regulates Translation Joseph Tcherkezian, Perry A. Brittis, Franziska Thomas,

The Landscape of Microsatellite Instability in Colorectal and Endometrial Cancer Genomes Tae-Min Kim, Peter W. Laird, Peter J. Park Cell Volume 155, Issue.

The Good Fat Cell Volume 147, Issue 7, (December 2011) DOI: /j.cell Copyright © 2011 Terms and Conditions Terms and Conditions.

A DNA-Dependent Protease Involved in DNA-Protein Crosslink Repair Julian Stingele, Michael S. Schwarz, Nicolas Bloemeke, Peter G. Wolf, Stefan Jentsch.

WHAMM Is an Arp2/3 Complex Activator That Binds Microtubules and Functions in ER to Golgi Transport Kenneth G. Campellone, Neil J. Webb, Elizabeth A. Znameroski,

CDK Inhibitors: Cell Cycle Regulators and Beyond Arnaud Besson, Steven F. Dowdy, James M. Roberts Developmental Cell Volume 14, Issue 2, Pages

Stable Kinesin and Dynein Assemblies Drive the Axonal Transport of Mammalian Prion Protein Vesicles Sandra E. Encalada, Lukasz Szpankowski, Chun-hong Xia,

Quantitative Single-Cell Approaches to Stem Cell Research Martin Etzrodt, Max Endele, Timm Schroeder Cell Stem Cell Volume 15, Issue 5, Pages (November.

Life without Centrioles: Cilia in the Spotlight

Gut Microbiota: The Link to Your Second Brain

Volume 29, Issue 5, Pages (November 2008)

Tumor Evolution: A Problem of Histocompatibility

Nek8 Couples Renal Ciliopathies to DNA Damage and Checkpoint Control

mTORC1: Turning Off Is Just as Important as Turning On

Volume 159, Issue 5, Pages (November 2014)

Vesicles Spread Susceptibility to Phages

Taking Snapshots of Ciliary Signaling

In This Issue Cell Volume 158, Issue 5, (August 2014)

Primary Cilia Bend LKB1 and mTOR to Their Will

Organizing Junctions at the Cell-Cell Interface

What's so Bor(a)ing about Aurora-A Activation?

Volume 152, Issue 1, (January 2013)

Retromer Sets a Trap for Endosomal Cargo Sorting

Volume 130, Issue 6, (September 2007)

Taking Vesicular Transport to the Cilium

Volume 134, Issue 2, Pages (July 2008)

Remembrance of Cilia Past

Tomer Avidor-Reiss, Michel R. Leroux Current Biology

The centrosome Current Biology

Volume 143, Issue 6, (December 2010)

Mitotic Inhibitors Journal of Thoracic Oncology

Peroxisomes: Another Branch of the Secretory Pathway?

MIS12/MIND Control at the Kinetochore

Pushing and Pulling: Microtubules Mediate Meiotic Pairing and Synapsis

Ciliary and Nuclear Transport: Different Places, Similar Routes?

A Kinase Gets Caspases into Shape

Mitosis sans Mitosis: The Mitotic Oscillator in Differentiation

Smoothing Out Drug Resistance

The chondrocyte primary cilium

A Kinesin in Command of Primary Ciliogenesis

Volume 54, Issue 5, Pages (June 2014)

Volume 163, Issue 4, (November 2015)

Chaos Controlled: Discovery of a Powerful Amyloid Inhibitor

Volume 163, Issue 2, (October 2015)

Volume 25, Issue 2, Pages (January 2007)

Volume 14, Issue 14, Pages R575-R577 (July 2004)

Navigating the Deubiquitinating Proteome with a CompPASS

Volume 134, Issue 6, (September 2008)

New Myc-anisms for DNA Replication and Tumorigenesis?

In This Issue Cell Volume 145, Issue 3, (April 2011)

Volume 148, Issue 1, (January 2012)

Targeting Protein Stability with a Small Molecule

Presentation transcript:

TTBK2 Kinase: Linking Primary Cilia and Cerebellar Ataxias Peter K. Jackson Cell Volume 151, Issue 4, Pages 697-699 (November 2012) DOI: 10.1016/j.cell.2012.10.027 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 Centriole Duplication Occurs during the Mitotic Cell Cycle Serum withdrawal induces cell-cycle exit and the recruitment of the centriole to the apical surface of cells via the distal appendage and dynein-based microtubule traffic to the subdistal appendage. The TTBK2 kinase is recruited to the centriole and transition zone near the ciliary base, and causes the loss of CP110, an inhibitor of axonemal growth, thereby licensing growth of the axoneme, assembly of the preciliary vesicle ciliary, and recruitment of intraflagellar transport proteins, including IFT-B. IFT-B plays an additional role in axonemal and ciliary membrane growth and in the maintenance of the mature cilium. Cell 2012 151, 697-699DOI: (10.1016/j.cell.2012.10.027) Copyright © 2012 Elsevier Inc. Terms and Conditions