Folate and Methylenetetrahydrofolate Reductase Polymorphisms: New Nutritional and Genetic Risk Factors for Pancreatic Cancer?  Young-In Kim, MD  Clinical.

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Folate and Methylenetetrahydrofolate Reductase Polymorphisms: New Nutritional and Genetic Risk Factors for Pancreatic Cancer?  Young-In Kim, MD  Clinical Gastroenterology and Hepatology  Volume 3, Issue 8, Pages 738-742 (August 2005) DOI: 10.1016/S1542-3565(05)00489-1 Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 1 Simplified scheme of folate metabolism. MTHFR catalyzes the irreversible conversion of 5,10-methyleneTHF to 5-methylTHF. B12, vitamin B12; DHFR, dihydrofolate reductase; CH3, methyl group; CpG, cytosine-guanine dinucleotide sequence; SAH, S-adenosylhomocysteine. Clinical Gastroenterology and Hepatology 2005 3, 738-742DOI: (10.1016/S1542-3565(05)00489-1) Copyright © 2005 American Gastroenterological Association Terms and Conditions

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