Endothelial expression of intercellular adhesion molecule 1 and vascular cell adhesion molecule 1 is suppressed by postbypass plasma containing increased.

Slides:

Advertisements

Similar presentations

The coronary delivery of marrow stromal cells for myocardial regeneration: Pathophysiologic and therapeutic implications Jih-Shiuan Wang, MD, Dominique.

Advertisements

Endothelial cell seeding reduces thrombogenicity of Dacron grafts in humans Per Örtenwall, MD, PhD *, Hans Wadenvik, MD, PhD **, Jack Kutti, MD, PhD **,

Resection of ascending aortic aneurysm without use of an interposition aortic graft John S. Ikonomidis, MD, PhD, FRCS(C), Abe DeAnda, MD, D.Craig Miller,

Pathologic N1 non-small cell lung cancer: Correlation between pattern of lymphatic spread and prognosis Alessandro Marra, MD, PhD, Ludger Hillejan, MD,

Suppressive effects of polyozellin on TGFBIp-mediated septic responses in human endothelial cells and mice Byeongjin Jung, Eun-Ju Yang, Jong-Sup Bae

Lost in translation The Journal of Thoracic and Cardiovascular Surgery

Volume 62, Issue 6, Pages (December 2002)

Ellagic acid inhibits oxidized LDL-mediated LOX-1 expression, ROS generation, and inflammation in human endothelial cells Wen-Jane Lee, PhD, Hsiu-Chung.

Sandhya K. Balaram, MD, Devendra K. Agrawal, PhD, R

Ellagic acid inhibits oxidized LDL-mediated LOX-1 expression, ROS generation, and inflammation in human endothelial cells Wen-Jane Lee, PhD, Hsiu-Chung.

Pretreatment with ω-3 fatty acid infusion to prevent leukocyte–endothelial injury responses seen in cardiac surgery Jonathan McGuinness, MD, PhD, John.

Association between n-3 polyunsaturated fatty acid content of red blood cells and inflammatory biomarkers in patients with peripheral artery disease

Association between n-3 polyunsaturated fatty acid content of red blood cells and inflammatory biomarkers in patients with peripheral artery disease

Microvascular responses to sepsis: clinical significance

Aspirin prevents resistin-induced endothelial dysfunction by modulating AMPK, ROS, and Akt/eNOS signaling Hsiu-Chung Ou, PhD, Wen-Jane Lee, PhD, Ching-Mei.

Endothelial hyperpermeability after cardiac surgery with cardiopulmonary bypass as assessed using an in vitro bioassay for endothelial barrier function

Sandhya K. Balaram, MD, Devendra K. Agrawal, PhD, R

Time-dependent cellular population of textured-surface left ventricular assist devices contributes to the development of a biphasic systemic procoagulant.

Right internal thoracic artery or saphenous vein grafting

William J. Dreyer, MDa, b, Sharon C. Phillips, BSa, Merry L

An anti-inflammatory property of aprotinin detected at the level of leukocyte extravasation George Asimakopoulos, FRCSa, Richard Thompson, MRCPb, Sussan.

The use of vancomycin paste to reduce sternal wound infections after cardiac surgery— why is this still a “sticky” subject Harold L. Lazar, MD The Journal.

Effect of retroviral transduction on human endothelial cell phenotype and adhesion to Dacron vascular grafts Ronald J. Jankowski, MS, Donald A. Severyn,

Cellular and mediator responses twenty-four hours after local endobronchial allergen challenge of asthmatic airways Anthony J. Frew, MD, Johanne St-Pierre,

Malcolm O. Perry, MD, Richard Kempczinski, MD

Recurrent thoracic outlet syndrome

Activation of Endothelial and Coagulation Systems in Left Ventricular Assist Device Recipients Ranjit John, MD, Sandhya Panch, MBBS, Jennifer Hrabe,

The lord of the rings Antonio Miceli, MD, PhD

Heart valves from pigs and the porcine endogenous retrovirus: Experimental and clinical data to assess the probability of porcine endogenous retrovirus.

Gastric conduit revision after esophagectomy: The raising of Lazarus

Jeffrey M. Rhodes, MD, Anna F. Tilberg, MS, Robert R.M. Gifford, MD

Endothelial Cell Injury in Cardiovascular Surgery: The Systemic Inflammatory Response1 Edward M Boyle, MD, Timothy H Pohlman, MD, Marion C Johnson, MD,

Support Your Specialty

Correction Journal of Vascular Surgery

Platelet-leukocyte activation and modulation of adhesion receptors in pediatric patients with congenital heart disease undergoing cardiopulmonary bypass

It's not “just a shunt” but sometimes it should be…

Valve interstitial cells induce donor-specific T-cell anergy

Joseph A. Dearani, MD, Michael J. Ackerman, MD, PhD

Production of proinflammatory cytokines and myocardial dysfunction after arterial switch operation in neonates with transposition of the great arteries

Intracellular calcium response of endothelial cells exposed to flow in the presence of thrombin or histamine Laura M. Worthen, MS, Matthias U. Nollert,

Reviewer Acknowledgment

Boulos Toursarkissian, MD, David Schwartz, MD, PhD, Paul R

We are the company we keep: The importance of the tumor microenvironment Sai Yendamuri, MD, FACS The Journal of Thoracic and Cardiovascular Surgery

Passing the torch The Journal of Thoracic and Cardiovascular Surgery

Pressure distension stimulates the expression of endothelial adhesion molecules in the human saphenous vein graft Massimo Chello, MD, Pasquale Mastroroberto,

Calvin B. Ernst, MD Journal of Vascular Surgery

Biomaterials for heart valve replacement: Conjectures and refutations

Mitral homografts for total tricuspid valve replacement: Comparison of two techniques Ulrik Hvass, MD, Frank Baron, MD, Dominique Fourchy, MD, Yves Pansard,

Chemokines and their receptors in allergic disease

Innovation in cardiothoracic surgical training

Regarding “Venous ulcers and the superficial venous system”

Constantine L. Athanasuleas, MD, FACC

Increased adhesion to vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 of eosinophils from patients with asthma Lena Håkansson,

The Journal of Thoracic and Cardiovascular Surgery

Discussion The Journal of Thoracic and Cardiovascular Surgery

Tai Ji: The law of inflammatory response

The future of cardiac surgery training: A survival guide

Apparently, size matters…in congenital heart disease and brain injury

Building a clinical program in a single institution

“The more things change…”: The challenges ahead

Toward a more rational approach in treating type B aortic dissection

Ryan R. Davies, MD The Journal of Thoracic and Cardiovascular Surgery

George D. Lilly 1906–1988 Journal of Vascular Surgery

Joachim Boldt, Bernd Kumle, Michael Papsdorf, Gunter Hempelmann

Preoperative PFTs: The answer is blowing in the wind

James A. DeWeese, MD Journal of Vascular Surgery

Perioperative renal function and thoracoabdominal aneurysm repair: Where do we go from here? Leonard N. Girardi, MD The Journal of Thoracic and Cardiovascular.

Of mice and men… The Journal of Thoracic and Cardiovascular Surgery

Journal changes and initiatives

Descending thoracic and thoracoabdominal aortic aneurysms: “Busted”

Presentation transcript:

Endothelial expression of intercellular adhesion molecule 1 and vascular cell adhesion molecule 1 is suppressed by postbypass plasma containing increased soluble intercellular adhesion molecule 1 and vascular cell adhesion molecule 1 Michael P. Vallely, MBBSa,b,c, Paul G. Bannon, FRACS, PhDb,c, Clifford F. Hughes, AO, FRACSb,c, Leonard Kritharides, FRACP, PhDa,d The Journal of Thoracic and Cardiovascular Surgery Volume 124, Issue 4, Pages 758-767 (October 2002) DOI: 10.1067/mtc.2002.123133 Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 1 Proinflammatory mediators are increased in circulating plasma after CPB: A, plasma IL-8; B, plasma CRP. Samples are defined in Table 1. *P <.05, **P <.01, and ***P <.001 relative to preoperative values (sample 1). Data are given as means ± SEM (n = 10). The Journal of Thoracic and Cardiovascular Surgery 2002 124, 758-767DOI: (10.1067/mtc.2002.123133) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 2 Plasma-soluble VCAM-1 and ICAM-1 increase after CPB: A, VCAM-1; B, ICAM-1; C, E-selectin. Samples are defined in Table 1. **P <.01 and ***P <.001 relative to preoperative values (sample 1). Data are given as means ± SEM (n = 10). The Journal of Thoracic and Cardiovascular Surgery 2002 124, 758-767DOI: (10.1067/mtc.2002.123133) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 3 HUVEC cell-surface VCAM-1 and ICAM-1 expression is suppressed by post-CPB plasma. HUVEC monolayers were incubated with CPB plasma. Cellular adhesion molecule expression was quantified by means of ELISA and expressed as a percentage of their expression on HUVECs incubated with pre-CPB plasma of the same subject (sample 1). Samples are defined in Table 1. *P <.05 and **P <.01 relative to preoperative values (sample 1). Data are given as means ± SEM (n = 10). The Journal of Thoracic and Cardiovascular Surgery 2002 124, 758-767DOI: (10.1067/mtc.2002.123133) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 4 IL-1β-activated HUVEC VCAM-1 and ICAM-1 expression is suppressed by post-CPB plasma: A, upregulation of HUVEC expression of VCAM-1, ICAM-1, and E-selectin by IL-1β in the presence of control preoperative plasma (P <.001 for comparison of control with IL-1β for each adhesion molecule); B-D, effect of post-CPB plasma on IL-1β-stimulated expression of VCAM-1 (B), ICAM-1 (C), and E-selectin (D). All values are expressed as a percentage expression of IL-1β-exposed pre-CPBB plasma (sample 1). Samples are defined in Table 1. *P <.05, **P <.01, and ***P <.001 relative to preoperative values (sample 1). Data are given as means ± SEM (n = 10). The Journal of Thoracic and Cardiovascular Surgery 2002 124, 758-767DOI: (10.1067/mtc.2002.123133) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 5 Plasma TGF-β1 and IL-10 are increased after CPB: A, TGF-β1; B, IL-10. Samples 1 to 5 are defined in Table 1. *P <.05, **P <.01, and ***P <.001 relative to preoperative values (sample 1). Data are given as means ± SEM (n = 10). The Journal of Thoracic and Cardiovascular Surgery 2002 124, 758-767DOI: (10.1067/mtc.2002.123133) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions