earching the best evidence

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Presentation transcript:

earching the best evidence Step: 2 S earching the best evidence

Categories of evidence I: RCT Ia: Evidence from meta-analysis of RCTS Ib: Evidence from at least one RCT II: Controlled trials IIa: Evidence from at least one controlled study without randomization IIb: Evidence from at least one controlled study with quasi-randomization III. Evidence from descriptive studies IV. Evidence from expert committee reports and/or clinical experience of respected authorities

Search strategy - Search term: keywords using PICO - Search Database Evidence-based database: systematic review & meta-analysis Medical database: original randomized controlled trial (RCT) - Study design/search Clinical trials Observational studies: cohort, case-control, cross-sectional

Four-part clinical question Is the antiretroviral prophylaxis given to pregnant women with HIV infection effective in reducing viral load and HIV mother-to-child transmission? Therapy Guideline for searching Search term: antiretrovirals and HIV and pregnant women Study design: RCT or systematic review Search database

Evidence-based databases Search database Evidence-based databases Medical database Clinical evidence CRD EBM online Cochrane Library PubMed Scientific information

PubMed http://www.ncbi.nlm.nih.gov/sites/entrez

Thank you