(A) Refined profile principal component analysis loading weights plot was used to derive insight into possible association of biomarkers. (A) Refined profile.

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Vitamin D3 increased ASL antimicrobial activity.

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(A) Refined profile principal component analysis loading weights plot was used to derive insight into possible association of biomarkers. (A) Refined profile principal component analysis loading weights plot was used to derive insight into possible association of biomarkers. (B) Correlation heatmap. Correlation matrix of refined profile subjected to hierarchical clustering using Pearson correlation as a distance metric. George Crowley et al. BMJ Open Resp Res 2018;5:e000274 ©2018 by British Thoracic Society