Practical Radiation Oncology

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Practical Radiation Oncology The Impact of Low-Dose Cranial Boost on the Long-Term Outcomes of Adult Patients with High-Risk Acute Lymphoblastic Leukemia Undergoing Total Body Irradiation and Allogeneic Hematopoietic Stem Cell Transplantation Justin M. Famoso, MD, Joel L. Grow, MD, Brady Laughlin, BS, Emmanuel Katsanis, MD, Baldassarre Stea, MD, PhD, FASTRO Practical Radiation Oncology DOI: 10.1016/j.prro.2018.12.005 Copyright © 2018 American Society for Radiation Oncology Terms and Conditions

Fig. 1 Kaplan-Meier probability curves for central nervous system (CNS) relapse-free survival according to CNS radiation boost patient groups. There was a statistically significant improvement in 7-year CNS relapse-free survival with the addition of a CNS radiation boost to total body irradiation conditioning regimens compared with patients who did not receive a boost (100% vs 76.4%; P = .043). Practical Radiation Oncology DOI: (10.1016/j.prro.2018.12.005) Copyright © 2018 American Society for Radiation Oncology Terms and Conditions

Fig. 2 Kaplan-Meier probability curves for progression-free survival according to central nervous system radiation boost patient groups. There was no statistically significant difference in 7-year progression-free survival with the addition of central nervous system radiation boosts to total body irradiation conditioning regimens compared with patients who did not receive a boost (78.3% vs 62.5%; P = .076). Practical Radiation Oncology DOI: (10.1016/j.prro.2018.12.005) Copyright © 2018 American Society for Radiation Oncology Terms and Conditions

Fig. 3 Kaplan-Meier probability curves for overall survival according to central nervous system radiation boost patient groups. There was no statistically significant difference in 7-year overall survival with the addition of a central nervous system radiation boost to total body irradiation conditioning regimens compared with patients who did not receive a boost (49.4% vs 43.5%; P = .921). Practical Radiation Oncology DOI: (10.1016/j.prro.2018.12.005) Copyright © 2018 American Society for Radiation Oncology Terms and Conditions