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A Treatment Algorithm for TRD Prof. Philip Cowen Professor of Psychopharmacology Department of Psychiatry University of Oxford, UK

Treatment algorithm for TRD

Treatment algorithm for TRD Every patient requires an individual assessment Treatment history Symptoms Extent of their disability

Treatment algorithm for TRD Every patient requires an individual assessment Treatment history Symptoms Extent of their disability

Cowen PJ, Anderson IM (2015). New approaches to treating resistant depression. BJPsych Advances 21, 315-323.

First line: Escitalopram Venlafaxine Cowen PJ, Anderson IM (2015). New approaches to treating resistant depression. BJPsych Advances 21, 315-323.

First line: Escitalopram: 20 mg/day Cowen PJ, Anderson IM (2015). New approaches to treating resistant depression. BJPsych Advances 21, 315-323.

Venlafaxine: up to 375 mg/day First line: Escitalopram: 20 mg/day Venlafaxine: up to 375 mg/day Cowen PJ, Anderson IM (2015). New approaches to treating resistant depression. BJPsych Advances 21, 315-323.

Venlafaxine: up to 375 mg/day First line: Escitalopram: 20 mg/day Venlafaxine: up to 375 mg/day Atypical antipsychotics Cowen PJ, Anderson IM (2015). New approaches to treating resistant depression. BJPsych Advances 21, 315-323.

Venlafaxine: up to 375 mg/day First line: Escitalopram: 20 mg/day Venlafaxine: up to 375 mg/day Atypical antipsychotics Mirtazapine Cowen PJ, Anderson IM (2015). New approaches to treating resistant depression. BJPsych Advances 21, 315-323.

Venlafaxine: up to 375 mg/day First line: Escitalopram: 20 mg/day Venlafaxine: up to 375 mg/day Atypical antipsychotics Mirtazapine Lithium Cowen PJ, Anderson IM (2015). New approaches to treating resistant depression. BJPsych Advances 21, 315-323.

Venlafaxine: up to 375 mg/day First line: Escitalopram: 20 mg/day Venlafaxine: up to 375 mg/day Atypical antipsychotics Mirtazapine Lithium TCAs Amitriptyline Clomipramine Cowen PJ, Anderson IM (2015). New approaches to treating resistant depression. BJPsych Advances 21, 315-323.

Venlafaxine: up to 375 mg/day First line: Escitalopram: 20 mg/day Venlafaxine: up to 375 mg/day Atypical antipsychotics Mirtazapine Lithium TCAs Amitriptyline Clomipramine MAOI Tryptophan Phenelzine Cowen PJ, Anderson IM (2015). New approaches to treating resistant depression. BJPsych Advances 21, 315-323.

Venlafaxine: up to 375 mg/day First line: Escitalopram: 20 mg/day Venlafaxine: up to 375 mg/day Atypical antipsychotics Mirtazapine Lithium TCAs Amitriptyline Clomipramine MAOI Tryptophan Phenelzine ECT Cowen PJ, Anderson IM (2015). New approaches to treating resistant depression. BJPsych Advances 21, 315-323.

Venlafaxine: up to 375 mg/day MAOI Phenelzine TCAs Amitriptyline Clomipramine First line: Escitalopram: 20 mg/day Venlafaxine: up to 375 mg/day Atypical antipsychotics Mirtazapine Lithium Psychotherapy CBT MBCBT Tryptophan ECT Cowen PJ, Anderson IM (2015). New approaches to treating resistant depression. BJPsych Advances 21, 315-323.

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