Tregs and APC subsets in TDLNs of patients with cervical cancer.

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Tregs and APC subsets in TDLNs of patients with cervical cancer. Tregs and APC subsets in TDLNs of patients with cervical cancer. A, more CD4+ Tregs as well as CD8+ FoxP3+ Tregs were present in LN+ compared with LN−. B, significantly higher percentages of DDCs, LCs, CD14+ APCs, CD14− LNDCs and no statistically significant differences for pDCs were found in LN+ compared with LN−. C, MFI of costimulatory surface molecules (CD40, CD80, CD83, and CD86) and coinhibitory surface molecules (PD-L1 and B7-H4) on CD14+ APCs in LN+ and LN−. MFI of PD-L1 on CD14+ APCs was significantly higher in LN+. Triple immunofluorescence staining of CD14 (green), CD163 (red), and PD-L1 (blue) of representative (D) tumor-negative (LN−) and (E) -positive (LN+) lymph node specimen reveals the presence of elevated numbers of CD14+CD163+ cells expressing PD-L1 in LN+ and low to no-detectable expression levels of PD-L1 on sporadic CD14+CD163+ cells in LN− (magnification, ×100; scale bar, 10 μm). F, scatter plot showing that increased levels of CD4+ Tregs (expressed as % of CD4+ T cells) were accompanied with significantly increased levels of CD14+ APCs and (G) CD14+ APCs expressing PD-L1 (expressed as MFI) in TDLNs of patients with cervical cancer. Dotted lines, 95% confidence interval of the regression line. Error bars, SEM. *, P = 0.01 to 0.05; **, P = 0.001 to 0.01; and ***, P < 0.001. A. Marijne Heeren et al. Cancer Immunol Res 2015;3:48-58 ©2015 by American Association for Cancer Research