RNA interference: It's a small RNA world

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RNA interference: It's a small RNA world Eric G Moss  Current Biology  Volume 11, Issue 19, Pages R772-R775 (October 2001) DOI: 10.1016/S0960-9822(01)00467-5

Fig. 1 The intersection of the siRNA and stRNA pathways, as suggested by recent work on C. elegans, Drosophila and human cells. Different double-stranded RNA precursors are processed by the same nuclease, Dicer. Members of Argonaute/RDE-1 protein family have roles in the generation and function of the small RNAs. Current Biology 2001 11, R772-R775DOI: (10.1016/S0960-9822(01)00467-5)

Fig. 2 The Argonaute/RDE-1 family and related proteins. Boxed proteins have been shown to be involved in post-transcriptional gene silencing, except for ALG-1/ALG-2, which are involved in stRNA generation. Other named proteins are involved in development. Some members of the family are not indicated. Current Biology 2001 11, R772-R775DOI: (10.1016/S0960-9822(01)00467-5)