Glomerular filtration: the charge debate charges ahead

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Presentation transcript:

Glomerular filtration: the charge debate charges ahead Jeffrey H. Miner Kidney International Volume 74, Issue 3, Pages 259-261 (August 2008) DOI: 10.1038/ki.2008.260 Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 1 The glomerular filtration barrier and the concept of charge selectivity. The three-layered barrier consists of the fenestrated endothelium, podocyte foot processes with bridging slit diaphragms, and the intervening glomerular basement membrane. Negative charge is associated with each of the three layers and is thought to retard filtration of anionic molecules (red) such as albumin, facilitate filtration of cationic molecules (green), and have little impact on neutral molecules (yellow). Kidney International 2008 74, 259-261DOI: (10.1038/ki.2008.260) Copyright © 2008 International Society of Nephrology Terms and Conditions