Figure 1 Histopathologic features of case 1 (A–G) and case 2 (H–L)‏

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Presentation transcript:

Figure 1 Histopathologic features of case 1 (A–G) and case 2 (H–L)‏ Histopathologic features of case 1 (A–G) and case 2 (H–L) (A–G) Case 1. (A) Hematoxylin and eosin (H&E) staining showing granulomas in endomysium. (B–D) Serial sections of a high-power view of the square area in (A) with (B) H&E staining and immunohistochemical analysis of (C) CD11 and (D) collagen IV CD11c+ M1 macrophages invading non-necrotic muscle fibers and forming granulomatous collection inside collagen IV-positive basal lamina. (E) CD8+ T cells infiltrating endomysium and invading non-necrotic fiber (arrows). (F) Scattered PD-1+ cells in granuloma and (G) PD-L1 overexpression on granuloma cells and non-necrotic fibers surrounding granuloma. (H–L) Case 2. (H) H&E staining of endomysial granuloma with multinucleated giant cell (arrow). Serial sections with (I) H&E staining and (J) immunohistochemical analysis of CD11 showing CD11c+ macrophages attacking non-necrotic fiber. Serial sections immunostained for (K) CD11c and (L) CD163 showing macrophages forming granulomatous collection within muscle fibers consisting of CD11c+ M1 and CD163+ M2 macrophages (arrows). Bars: 50 μm for A, E, F, G, H, K, and L, and 10 μm for B, C, D, I, and J. PD-1 = programmed death-1; PD-L1 = programmed death-ligand 1. Naohiro Uchio et al. Neurol Neuroimmunol Neuroinflamm 2018;5:e464 Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.