Volume 25, Issue 1, Pages 5-7 (January 2017)

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Volume 25, Issue 1, Pages 5-7 (January 2017) Orchestrating a Symphony on a Single Conjugate: Aptamer Targeting, Gene Silencing, and Immunomodulation to Enhance Antitumor Response Brandon D. Ng, Dan Peer Molecular Therapy Volume 25, Issue 1, Pages 5-7 (January 2017) DOI: 10.1016/j.ymthe.2016.12.003 Copyright © 2017 The American Society of Gene and Cell Therapy Terms and Conditions

Figure 1 CD8+ T Cell Differentiation Mediated by the 4-1BB Aptamer-CD25 siRNA Conjugate Upper path (with aptamer-siRNA conjugate) shows differentiation into MPECs, while the lower path (without aptamer-siRNA conjugate) shows differentiation into SLECs and eventual apoptosis. Molecular Therapy 2017 25, 5-7DOI: (10.1016/j.ymthe.2016.12.003) Copyright © 2017 The American Society of Gene and Cell Therapy Terms and Conditions