1. A Theranostic “SMART” Aptamer for Targeted Therapy of Prostate Cancer
Vittorio de Franciscis 
Molecular Therapy 
Volume 22, Issue 11, Pages (November 2014)
DOI: /mt
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2. Figure 1
In vivo therapeutic efficacy of the A9g PSMA aptamer. By binding prostate-specific membrane antigen (PSMA), the A9g aptamer blocks NAALADase/glutamate carboxypeptidase II activity and inhibits PSMA-dependent cell migration and invasion in cancer cells in a mouse model of metastatic prostate cancer. Severe combined immunodeficiency mice were treated with the indicated aptamers and analyzed following injection of luciferase-expressing PSMA-positive prostate cancer cells. Modified from ref. 3.
Molecular Therapy  , DOI: ( /mt )
Copyright © 2014 American Society of Gene & Cell Therapy Terms and Conditions