Mikkel Rosendahl, M. D. , Claus Yding Andersen, D. M. Sc

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Presentation transcript:

Dynamics and mechanisms of chemotherapy-induced ovarian follicular depletion in women of fertile age Mikkel Rosendahl, M.D., Claus Yding Andersen, D.M.Sc., Nina la Cour Freiesleben, M.D., Anders Juul, M.D., D.M.Sc., Kristine Løssl, M.D., Ph.D., Anders Nyboe Andersen, M.D., D.M.Sc. Fertility and Sterility Volume 94, Issue 1, Pages 156-166 (June 2010) DOI: 10.1016/j.fertnstert.2009.02.043 Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

Figure 1 The time of visits in relation to chemotherapy and menstrual cycle. Fertility and Sterility 2010 94, 156-166DOI: (10.1016/j.fertnstert.2009.02.043) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Mean levels (± SEM) of markers of ovarian function during chemotherapy 1–8. (A) The day before and (B) 1 week after a treatment. Pyramids indicate 1 week after a series of chemotherapy. Fertility and Sterility 2010 94, 156-166DOI: (10.1016/j.fertnstert.2009.02.043) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

Figure 3 The development of levels of AMH and inhibin B after the first series of chemotherapy for patients who had an ovary removed between the two visits (n = 8) and patients with two ovaries (n = 9). Mean levels (± SEM). Fertility and Sterility 2010 94, 156-166DOI: (10.1016/j.fertnstert.2009.02.043) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

Figure 4 Ovarian function during the recovery period after the end of chemotherapy. Mean levels (± SEM). Fertility and Sterility 2010 94, 156-166DOI: (10.1016/j.fertnstert.2009.02.043) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions