Local anaesthetic-induced myotoxicity in regional anaesthesia: a systematic review and empirical analysis N. Hussain, C.J.L. McCartney, J.M. Neal, J.

Slides:

Advertisements

Similar presentations

Methods of Rotation From Another Strong Opioid to Methadone for the Management of Cancer Pain: A Systematic Review of the Available Evidence Sarah McLean,

Advertisements

Efficacy of perineural vs systemic dexamethasone to prolong analgesia after peripheral nerve block: a systematic review and meta-analysis M. Baeriswyl,

Paravertebral block in paediatric abdominal surgery'a systematic review and meta- analysis of randomized trials E.A. Page, K.L. Taylor British Journal.

Locoregional anesthesia for endovascular aneurysm repair

Predictors of acute diverticulitis severity: A systematic review

M. Chazapis, D. Gilhooly, A. F. Smith, P. S. Myles, G. Haller, M. P. W

Cerebrospinal-fluid drain-related complications in patients undergoing open and endovascular repairs of thoracic and thoraco-abdominal aortic pathologies:

Hants Williams, PhD (C), BSN, RN, Paula Tanabe, PhD, RN, FAEN, FAAN

Systematic review of the systemic concentrations of local anaesthetic after transversus abdominis plane block and rectus sheath block J. Rahiri, J. Tuhoe,

Methods of Rotation From Another Strong Opioid to Methadone for the Management of Cancer Pain: A Systematic Review of the Available Evidence Sarah McLean,

E.M. Wesselink, T.H. Kappen, H.M. Torn, A.J.C. Slooter, W.A. van Klei

Efficacy and adverse effects of buprenorphine in acute pain management: systematic review and meta-analysis of randomised controlled trials L.D. White,

Locoregional anesthesia for endovascular aneurysm repair

Screening for abdominal aortic aneurysm in asymptomatic adults

Effect of combining tramadol and morphine in adult surgical patients: a systematic review and meta-analysis of randomized trials V. Martinez, L. Guichard,

β-Agonists and metabolism

Cost-effectiveness of a systematic e-assessed follow-up of postoperative recovery after day surgery: a multicentre randomized trial K. Dahlberg, A. Philipsson,

G. Xu, H. Lu, Y. Dong, D. Shapoval, S. G. Soriano, X. Liu, Y. Zhang, Z

Incidence of iatrogenic opioid dependence or abuse in patients with pain who were exposed to opioid analgesic therapy: a systematic review and meta-analysis

The impact of neuraxial clonidine on postoperative analgesia and perioperative adverse effects in women having elective Caesarean section–a systematic.

Robert Kantor, BS, Prarthana Dalal, BS, David Cella, PhD, Jonathan I

Ultrasound-guided radial artery cannulation in adult and paediatric populations: a systematic review and meta-analysis Leigh White, Alice Halpin, Marianne.

A different use of visual analytic techniques in anaesthetics

Non-steroidal anti-inflammatory drugs in the oncological surgical population: beneficial or harmful? A systematic review of the literature J.P. Cata,

Barriers to clinical research in Africa: a quantitative and qualitative survey of clinical researchers in 27 African countries A. Conradie, R. Duys,

Evidence basis for using perineural dexmedetomidine to enhance the quality of brachial plexus nerve blocks: a systematic review and meta-analysis of randomized.

Perioperative psychotherapy for persistent post-surgical pain and physical impairment: a meta-analysis of randomised trials L. Wang, Y. Chang, S.A. Kennedy,

M.A. Olympio, R. Whelan, R.P.A. Ford, I.C.M. Saunders

Should continuous rather than single-injection interscalene block be routinely offered for major shoulder surgery? A meta-analysis of the analgesic and.

Pain after orthopaedic surgery: differences in patient reported outcomes in the United States vs internationally. An observational study from the PAIN.

Measuring non-technical skills of anaesthesiologists in the operating room: a systematic review of assessment tools and their measurement properties

A systematic review and evidence synthesis of qualitative studies to identify primary care clinicians' barriers and enablers to the management of osteoarthritis

Death and its diagnosis by doctors

Neuromuscular junction in health and disease

Correction to the paper ‘Delivery of tidal volume from four anaesthesia ventilators during volume-controlled ventilation: a bench study’ M Hallbäck,

Does regional anaesthesia improve outcome after total hip arthroplasty

Psychology of pain British Journal of Anaesthesia

Do team processes really have an effect on clinical performance

Steroids in cardiac surgery: a systematic review and meta-analysis

Efficacy and adverse effects of ketamine as an additive for paediatric caudal anaesthesia: a quantitative systematic review of randomized controlled trials†

Palliative Care Screening and Assessment in the Emergency Department: A Systematic Review Naomi George, MD, Elizabeth Phillips, MD, Milana Zaurova, MD,

The output of two sevoflurane vaporizers in the presence of helium

Distraction and interruption in anaesthetic practice

Uvula necrosis after fibreoptic intubation

The Latest Waves in Calcium Signaling

Calcium sensitizers: What have we learned over the last 25years?

Interstitial muscle concentrations of rocuronium under steady-state conditions in anaesthetized dogs: actual versus predicted values Ezzine S. , Varin.

Incidence, characteristics, and predictive factors for medication errors in paediatric anaesthesia: a prospective incident monitoring study C. Gariel,

Falls and major orthopaedic surgery with peripheral nerve blockade: a systematic review and meta-analysis R.L. Johnson, S.L. Kopp, J.R. Hebl, P.J. Erwin,

A. W. H. Barazanchi, W. S. MacFater, J. -L. Rahiri, S. Tutone, A. G

Eugene Braunwald JCHF 2013;1:1-20

The association between obesity and disability in survivors of joint surgery: analysis of the health and retirement study T.G. Gaulton, L.A. Fleisher,

Ketamine: a growing global health-care need

Heterogeneity of studies in anesthesiology systematic reviews: a meta-epidemiological review and proposal for evidence mapping B. Umberham, R. Hedin,

Ultrasound reduces the minimum effective local anaesthetic volume compared with peripheral nerve stimulation for interscalene block A McNaught, U Shastri,

Teamwork, communication, and anaesthetic assistance in Scotland

Diffusion of nitrous oxide into the pleural cavity†

T. Greco, M. G. Calabrò, R. D. Covello, M. Greco, L. Pasin, A

P.E. Vlisides, M.S. Avidan, G.A. Mashour

Systematic review of the QoR-15 score, a patient- reported outcome measure measuring quality of recovery after surgery and anaesthesia J. Kleif, J. Waage,

Cervical epidural analgesia in current anaesthesia practice: systematic review of its clinical utility and rationale, and technical considerations H.

Influence of head and neck position on ventilation using the air-Q® SP airway in anaesthetized paralysed patients: a prospective randomized crossover.

M. J. Sheen, S. -T. Ho, C. -H. Lee, Y. -C. Tsung, F. -L. Chang, S. -T

A systematic review of rescue analgesic strategies in acute exacerbations of primary trigeminal neuralgia D. Moore, M.S. Chong, A. Shetty, J.M. Zakrzewska

Perioperative diabetic ketoacidosis associated with sodium-glucose co-transporter-2 inhibitors: a systematic review Venkatesan Thiruvenkatarajan, Emily.

Effect of concentration of local anaesthetic solution on the ED50 of bupivacaine for supraclavicular brachial plexus block† P.K. Gupta, P.M. Hopkins

Comparison of nebulised dexmedetomidine, ketamine, or midazolam for premedication in preschool children undergoing bone marrow biopsy H.S. Abdel-Ghaffar,

Adjunct endovascular interventions in carotid body tumors

Shuai Zeng, Bing Li, Shaoqun Zeng, Shangbin Chen Biophysical Journal

Fig. 2. Potential mechanisms and effects of impaired Ca2+ handling in DC. Impairment in cardiomyocyte Ca2+ influx and efflux, impaired release and reuptake.

Presentation transcript:

Local anaesthetic-induced myotoxicity in regional anaesthesia: a systematic review and empirical analysis N. Hussain, C.J.L. McCartney, J.M. Neal, J. Chippor, L. Banfield, F.W. Abdallah British Journal of Anaesthesia Volume 121, Issue 4, Pages 822-841 (October 2018) DOI: 10.1016/j.bja.2018.05.076 Copyright © 2018 British Journal of Anaesthesia Terms and Conditions

Fig 1 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow diagram depicting the flow of information through the various phases of this systematic review. British Journal of Anaesthesia 2018 121, 822-841DOI: (10.1016/j.bja.2018.05.076) Copyright © 2018 British Journal of Anaesthesia Terms and Conditions

Fig 2 Adapted illustration from Neal and colleagues (2013),44 which describes myotoxicity at a cellular level. When myocytes are exposed to local anaesthetic (LA), cytoplasmic calcium (Ca2+) concentrations increase as a result of the direct action on the sarcoplasmic reticulum or the ryanodine receptors (RyRs). Impaired mitochondrial Ca2+ reuptake reduces cellular energy production [conversion of adenosine diphosphate (ADP) to adenosine triphosphate (ATP)]. LAs may also suppress clearance of cytoplasmic Ca2+ at the sarcoplasmic–endoplasmic reticulum Ca2+-ATPase (SERCA) and at the plasma membrane Ca2+ ATPase (PMCA). British Journal of Anaesthesia 2018 121, 822-841DOI: (10.1016/j.bja.2018.05.076) Copyright © 2018 British Journal of Anaesthesia Terms and Conditions