Increased susceptibility of hypertrophied hearts to ischemic injury

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Increased susceptibility of hypertrophied hearts to ischemic injury Ingeborg Friehs, MD, Pedro J del Nido, MD The Annals of Thoracic Surgery Volume 75, Issue 2, Pages S678-S684 (February 2003) DOI: 10.1016/S0003-4975(02)04692-1

Fig 1 (A) Left ventricular mass–to–cavity volume measurement as an indicator of progression of hypertrophy (black circles). After an initial peak at 4 weeks of age in animals with hypertrophied hearts, there is a gradual decline indicative of ventricular dilation (n = 6/group). *p ≤ 0.05 vs control (empty circles). (B) Measurement of contractility, depicted as shortening fraction, indicates that myocardial function deteriorates as hypertrophy (black circles) progresses into failure (n = 6/group). *p ≤ 0.05 vs control (empty circles). The Annals of Thoracic Surgery 2003 75, S678-S684DOI: (10.1016/S0003-4975(02)04692-1)

Fig 2 Glucose uptake was measured as accumulation of 2-deoxyglucose-6-phosphate (2-DG) by 31P–nuclear magnetic resonance spectroscopy over a 30-minute period in isolated perfused hearts. There is significantly impaired glucose uptake in hypertrophied (black circles) hearts (n = 6/group). *p ≤ 0.05 vs control (empty circles). The Annals of Thoracic Surgery 2003 75, S678-S684DOI: (10.1016/S0003-4975(02)04692-1)

Fig 3 Myocardial 3H-O-methyl glucose uptake was determined in 6-week-old control and aortic-banded rabbits (n = 6/group). Glucose uptake is significantly decreased in hypertrophied (black rectangle) hearts in vivo. *p ≤ 0.05 vs control (empty rectangle). The Annals of Thoracic Surgery 2003 75, S678-S684DOI: (10.1016/S0003-4975(02)04692-1)

Fig 4 Representative Western immunoblot of GLUT-1 (top row) and GLUT-4 (bottom row) expression. There was no significant difference in protein levels in hypertrophied versus nonhypertrophied, age-matched control hearts. The Annals of Thoracic Surgery 2003 75, S678-S684DOI: (10.1016/S0003-4975(02)04692-1)

Fig 5 Glucose uptake after 30 minutes of normothermic ischemia, returned to preischemic levels 15 minutes into reperfusion and remained significantly lower in hypertrophied (black circles) hearts (n = 6/group). *p ≤ 0.05 vs control (empty circles). 2-DG = 2-deoxyglucose-6-phosphate. The Annals of Thoracic Surgery 2003 75, S678-S684DOI: (10.1016/S0003-4975(02)04692-1)

Fig 6 (A) Representative sections of hearts from aorta-banded and control animals stained with CD-31 as primary antibody and a fluorescent secondary antibody. Number of microvessels detected is lower in hypertrophied myocardium. (B) FITC-labeled, lectin-stained cross sections showed lower numbers of microvessels in hypertrophied hearts than in controls. (Left panels = control; right panels = hypertrophy.) The Annals of Thoracic Surgery 2003 75, S678-S684DOI: (10.1016/S0003-4975(02)04692-1)