Device for controllable administration of drug dosage Graduation Project I Device for controllable administration of drug dosage Prepared By: - Mona Ibrahim 200002091 - Azza Al Hassani 200002019 - Asma Ahmed 200002020 - Hamda Al Ketbi 199902209 - Moza Al Shamsi 199903856 Adviser’s name: - Dr. Yousef Haik

Presentation Layout Motivation Objectives Design Process Testing Device Dispensing Device Communication Device Conclusion

Motivation

Project Description Dispensing Device Testing Device Physician Patient

Blood Clotting A natural process in which blood cells and fibrin strands clump together to stop bleeding

Blood Coagulation Mechanism

Prothrombin Time (PT) The time it takes plasma to clot. PT is reported in seconds

International Normalization Ratio (inr) The ratio of the patient's clotting time to the mean reference value.

Anticoagulants Medications that delay the coagulation of blood Some of these are: Heparin Argatroban Hirudin Warfarin

Warfarin the most widely used oral anticoagulant. It is a non-habit forming medication. to prevent formation of new blood clots in high-risk patients

Motivation Frequent Monitoring Dose adjustment Reduce patient error Time saving Availability of a patient medical history Reduce visitation to clinic.

Objectives Design a blood testing mechanism Design a drug dispensing mechanism Design and construct a working prototype of the system Dispensing Device Testing Device Physician Patient

Design Process Gantt Chart

The Harmony INR Monitoring System Market Analysis The ProTime System-PT- INR Testing The Harmony INR Monitoring System Coaguchek System INRatio®PT Monitoring System

Function Structure Global device function Overall function structure Drug dose Blood sample System Blood Sample Testing Device Dispenser Communicator INR value Dose Drug Dosage Hold Sample Overall function structure

Specifications Measuring Device Dispensing Device

Measuring Device Touch button operation Small sample volume: 20 µL Portable and easy to use Large, easy to read reporting screen Durable Repeatable Cost effective meter and test strip Dimension 5"×3" Small sample volume: 20 µL Perform measurement automatically as soon as the sample is applied Measuring time is less than one minute Sensitive: can measure less than 1 mg/mL of Prothrombin Made of biocompatible materials Disposable sample holder Meet the International Biomedical Instrumentation standards

Dispensing Device Store medicine Cost effective Dispense one tablet at the time Time for dispensing to be less than 2 minutes Patient interference to the device is negligible Cost effective Durable Dimension 5”×2.5” Safe, no sharp corner

Communication Device Cost effective Dimension 5”×3” Communication between the medical doctor and the device within one day The whole device dimension should not exceed 26.5"×12"

Developing concepts

Testing Morphological Chart Hold Sample Testing methods 1.RLC 2. Protein separation 3. Contact angle 4. Plasma profile 5. Viscosity 6. Light intensity 7. Shear stress 8.Charged Particle 9.Elisa 10.Cantilever beam 11.Piezoelectric 12. Blood layer thickness Display INR Digital display Printer LED monitor LCD

Testing Methods 1. RLC Testing Method

Experiments Measuring the capacitance across the copper plates with time

experiments Measuring the capacitance across the copper plates with time for different INR values (adding tissue factor)

Contact angle Method

Contact angle measurements Result θ is too small to measure Syringe camera sample stage light source Measure surface area Captive Bubble Contact Angle apparatus

Surface Area method

Protein Separation Method

viscosity Method Resistance measurements Charged particle Method

Shear stress Measuring the distance moved

Light intensity Blood layer thickness

Cantilever beam Method Plasma profile Method More

viscosity Method

Charged particle Method + - Function Generator

piezoelectric Method Flow in pipes

Drug dispensing device

dispenser Morphological Chart Tablet Holder Mover Belt Shaft Gear Pulleys Manual Rollers Piston

dispenser Morphological Chart Actuator Dc motor pneumatic hydraulic Step motor count IR sensor Laser Sensor Distance Sensor Lock solenoid Worm gear Spring damping Spring solenoid arm locking (hook)

dispenser Morphological Chart Cutter cutter Scissors (Sharp) Paper cutter Utility Knife Ejector

Dispensing concept 1

Dispensing concept 2

Dispensing concept 3

Dispensing concept 4

Dispensing concept 5

Communication device

communication Morphological Chart Sending signals Wire modem Sound Fiber optic Laser transmitter

Cost estimation

The budget

Testing device

Dispensing device

Communication part

Experimental part

CONCLUSION

FUTURE WORK Resuming investigating the testing methods Evaluating testing methods to select the proper one Analyzing the design of testing, dispensing, and communication Building a prototype for the whole device Experiments

Tasks

GANTT CHART