Delayed immune reconstitution after allogeneic transplantation increases the risks of mortality and chronic GVHD by Nelli Bejanyan, Claudio G. Brunstein, Qing Cao, Aleksandr Lazaryan, Xianghua Luo, Julie Curtsinger, Rohtesh S. Mehta, Erica Warlick, Sarah A. Cooley, Bruce R. Blazar, Jeffrey S. Miller, Daniel Weisdorf, John E. Wagner, and Michael R. Verneris BloodAdv Volume 2(8):909-922 April 24, 2018 © 2018 by The American Society of Hematology

Nelli Bejanyan et al. Blood Adv 2018;2:909-922 © 2018 by The American Society of Hematology

Immune reconstitution after MSD vs UCB RIC allogeneic transplant. Immune reconstitution after MSD vs UCB RIC allogeneic transplant. (A) Absolute lymphocyte count; (B) total NK cells (CD3−CD56+); (C) total CD3+ T cells; (D) total CD8+ T cells; (E) total CD4+ T cells; (F) naïve CD4+ T cells (CD45RA+CD27+); (G) T regulatory cells (CD4+CD25bright CD127); and (H) B cells. The boxes show the interquartile range of absolute cell count (/μL) for each immune cell type. The bold horizontal lines inside the boxes indicate the median absolute cell count (/μL); the whiskers represent 1.5× the height of the box (or minimum/maximum values if there is no value in that range); and the circles indicate the outliers. Nelli Bejanyan et al. Blood Adv 2018;2:909-922 © 2018 by The American Society of Hematology

Immune reconstitution after MSD vs UCB RIC allogeneic transplant. Immune reconstitution after MSD vs UCB RIC allogeneic transplant. (A) Absolute lymphocyte count; (B) total NK cells (CD3−CD56+); (C) total CD3+ T cells; (D) total CD8+ T cells; (E) total CD4+ T cells; (F) naïve CD4+ T cells (CD45RA+CD27+); (G) T regulatory cells (CD4+CD25bright CD127); and (H) B cells. The boxes show the interquartile range of absolute cell count (/μL) for each immune cell type. The bold horizontal lines inside the boxes indicate the median absolute cell count (/μL); the whiskers represent 1.5× the height of the box (or minimum/maximum values if there is no value in that range); and the circles indicate the outliers. Nelli Bejanyan et al. Blood Adv 2018;2:909-922 © 2018 by The American Society of Hematology

Infection density. Infection density. (A) Infection density by donor type and post-HCT time period. (B) Infection density at days 29 to 365 by lower and higher absolute cell counts. Nelli Bejanyan et al. Blood Adv 2018;2:909-922 © 2018 by The American Society of Hematology