Beneficial Effects of Fluosol–Polyethylene Glycol Cardioplegia on Cold, Preserved Rabbit Heart Joginder N Bhayana, MD, Zhong T Tan, MD, PhD, Jacob Bergsland,

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Presentation transcript:

Beneficial Effects of Fluosol–Polyethylene Glycol Cardioplegia on Cold, Preserved Rabbit Heart Joginder N Bhayana, MD, Zhong T Tan, MD, PhD, Jacob Bergsland, MD, Daya Balu, MD, Jaswant K Singh, MD, Eddie L Hoover, MD The Annals of Thoracic Surgery Volume 63, Issue 2, Pages 459-464 (February 1997) DOI: 10.1016/S0003-4975(96)01100-9

Fig. 1 Left ventricular compliance at the end of reperfusion after preservation. In comparison with group I, ∗p < 0.05 and ∗∗p < 0.01 at 0 or 25 mm Hg left ventricular end-diastolic pressure (LVEDP). In comparison with group II, ∗p < 0.05. Group IV versus group V = p > 0.05. The Annals of Thoracic Surgery 1997 63, 459-464DOI: (10.1016/S0003-4975(96)01100-9)

Fig. 2 Myocardial high-energy phosphate contents at the end of reperfusion after preservation. In comparison with group I, ∗p < 0.01 and ∗∗p < 0.001. Group V versus groups II, III, and IV = p < 0.01. (ATP = adenosine triphosphate; CP = creatinine phosphate.) The Annals of Thoracic Surgery 1997 63, 459-464DOI: (10.1016/S0003-4975(96)01100-9)

Fig. 3 Activities of lactate dehydrogenase (LDH) released from reperfused heart after preservation. In comparison with group I, ∗p < 0.01 and ∗∗p < 0.001. Group V versus groups II, III, and IV = p < 0.001. The Annals of Thoracic Surgery 1997 63, 459-464DOI: (10.1016/S0003-4975(96)01100-9)

Fig. 4 Group II. (A) Marked edema with loss of myofibrils (long black arrows). Edema and swelling of mitochondria (black arrowheads). (×7000 before 47% reduction.) (B) Mitochondria showed amorphous and granular densities (long black arrows). Swelling of cristae and increase in matrix space with edema of mitochondria (black arrowheads). (×21,000 before 43% reduction.) The Annals of Thoracic Surgery 1997 63, 459-464DOI: (10.1016/S0003-4975(96)01100-9)

Fig. 5 Group IV. (A) Normal myofibrillar arrangement (long white arrows) and closely packed, normal-appearing mitochondria (long black arrows). (×8,000 before 37% reduction.) (B) Normal-appearing mitochondria (long black arrows) in association with glycogen (white arrowheads). (×24,000 before 37% reduction.) The Annals of Thoracic Surgery 1997 63, 459-464DOI: (10.1016/S0003-4975(96)01100-9)