Volume 15, Issue 6, Pages (May 2014)

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Volume 15, Issue 6, Pages 620-630 (May 2014) Adjuvant bevacizumab in patients with melanoma at high risk of recurrence (AVAST-M): preplanned interim results from a multicentre, open-label, randomised controlled phase 3 study Dr Pippa G Corrie, PhD, Andrea Marshall, PhD, Prof Janet A Dunn, PhD, Prof Mark R Middleton, PhD, Paul D Nathan, PhD, Prof Martin Gore, PhD, Prof Neville Davidson, FRCP, Steve Nicholson, PhD, Charles G Kelly, FRCR, Maria Marples, PhD, Sarah J Danson, PhD, Ernest Marshall, MD, Stephen J Houston, MD, Ruth E Board, PhD, Ashita M Waterston, PhD, Jenny P Nobes, FRCR, Mark Harries, PhD, Satish Kumar, MD, Gemma Young, MPhil, Paul Lorigan, MD The Lancet Oncology Volume 15, Issue 6, Pages 620-630 (May 2014) DOI: 10.1016/S1470-2045(14)70110-X Copyright © 2014 Corrie et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 1 Trial profile HR=hazard ratio. *Patients were included in the longitudinal quality-of-life analysis if they had completed at least two questionnaires. The Lancet Oncology 2014 15, 620-630DOI: (10.1016/S1470-2045(14)70110-X) Copyright © 2014 Corrie et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 2 Overall survival (A) and distant metastasis-free interval (B), analysis unadajusted for stratification factors HR=hazard ratio. The Lancet Oncology 2014 15, 620-630DOI: (10.1016/S1470-2045(14)70110-X) Copyright © 2014 Corrie et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 3 Disease-free interval for all patients (A), for patients with a BRAF mutation (B), and for those with BRAF wild type (C) HR=hazard ratio. The Lancet Oncology 2014 15, 620-630DOI: (10.1016/S1470-2045(14)70110-X) Copyright © 2014 Corrie et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 4 Hazard ratio plot of the treatment effect by prognostic factors for disease-free interval O–E=observed–expected events. HR=hazard ratio. The Lancet Oncology 2014 15, 620-630DOI: (10.1016/S1470-2045(14)70110-X) Copyright © 2014 Corrie et al. Open Access article distributed under the terms of CC BY Terms and Conditions