Volume 54, Issue 6, Pages (January 1998)

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Volume 54, Issue 6, Pages 2037-2044 (January 1998) Nephroprotection by long-term ACE inhibition with ramipril in spontaneously hypertensive stroke prone rats Wolfgang Linz, Reinhard H.A. Becker, Bernward A. Schölkens, Gabriele Wiemer, Manfred Keil, Karl Heinz Langer Kidney International Volume 54, Issue 6, Pages 2037-2044 (January 1998) DOI: 10.1046/j.1523-1755.1998.00208.x Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 1 Overview of the kidney cortex (A) with arterial, glomerular and tubulointerstitial injuries in placebo-treated SHR-SP, (B) minor changes after LRA treatment (non-antihypertensive dose of ramipril, 10 μg · kg-1· d-1), and (C) no changes after HRA treatment (antihypertensive dose of ramipril, 1mg · kg-1· d-1). PEARSE staining, magnification a - c ×52. Kidney International 1998 54, 2037-2044DOI: (10.1046/j.1523-1755.1998.00208.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 2 Arteriae intralobulares after placebo (A and B) and after LRA treatment (see Figure 1) (C and D). (A) media hypertrophy and sclerosis and (B) fibrinoid necrosis and periarteritis (like panarteritis nodosa); (C) minimal hypertrophy and no intimal sclerosis, and (D) fibrinoid necrosis, but not combined with periarteritis. PEARSE staining, magnification A, C, D ×330, B ×130. Kidney International 1998 54, 2037-2044DOI: (10.1046/j.1523-1755.1998.00208.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 3 Glomeruli after placebo (A and B) and LRA treatment (see Figure 1 (C and D). (A) fibrinoid necrosis in microcystic capillary loops, (B) sclerosis with capillary obliteration; (C) enlarged glomerulum (like that in A) with widened capillary loops juxtamedullary typical for hypertension, (D) capillary sclerosis with capsular adherence besides a normal glomerulum. PEARSE staining, magnification A - C ×330, D ×130. Kidney International 1998 54, 2037-2044DOI: (10.1046/j.1523-1755.1998.00208.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 4 After HRA treatment (see Figure 1), arteria arcuata (cross section below) and intralobularis, glomerula and tubulointerstitial area are without any change. PEARSE staining, magnification ×130. Kidney International 1998 54, 2037-2044DOI: (10.1046/j.1523-1755.1998.00208.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 5 Scatterplot correlation matrix with normal curve density display of blood pressure (BP), plasma angiotensin converting enzyme (ACE), kidney ACE activity, and histomorphological score (Score). Symbols are: red (•) placebo; blue (▴) HRA; and black (□) LRA (see Figure 1 for definitions). Kidney International 1998 54, 2037-2044DOI: (10.1046/j.1523-1755.1998.00208.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 2037-2044DOI: (10. 1046/j. 1523-1755 Kidney International 1998 54, 2037-2044DOI: (10.1046/j.1523-1755.1998.00208.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 2037-2044DOI: (10. 1046/j. 1523-1755 Kidney International 1998 54, 2037-2044DOI: (10.1046/j.1523-1755.1998.00208.x) Copyright © 1998 International Society of Nephrology Terms and Conditions