Inhibitory effect of photooxidation on intimal and medial thickening of saphenous vein Jyotirmay Chanda , MD, Ryosei Kuribayashi, MD, Ke-Xiang Liu, MD,

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Presentation transcript:

Inhibitory effect of photooxidation on intimal and medial thickening of saphenous vein Jyotirmay Chanda , MD, Ryosei Kuribayashi, MD, Ke-Xiang Liu, MD, Yoshiki Shibata, MD The Annals of Thoracic Surgery Volume 66, Issue 2, Pages 449-454 (August 1998) DOI: 10.1016/S0003-4975(98)00444-5

Fig 1 Cryosection of photooxidized (A) and freshly isolated (B) vein segments stained with Live/Dead Reduced Biohazard Viability Cytotoxicity Kit. Live endothelial cells are stained green (solid arrow) and dead endothelial cells (open arrow) are red. The fluorescence intensity of live cells is significantly lower than that of dead cells. Notice photooxidation for 5 minutes does not affect the viability of the endothelial cells in comparison with those of freshly isolated vein. (×100 before 35% reduction.) The Annals of Thoracic Surgery 1998 66, 449-454DOI: (10.1016/S0003-4975(98)00444-5)

Fig 2 Light photomicrographs show that the endothelial layer (arrow) of both photooxidized (A) and nonphotooxidized (B) vein segments remains intact after culture for 21 days. (Anti–von Willebrand factor stain; ×100 before 32% reduction.) The Annals of Thoracic Surgery 1998 66, 449-454DOI: (10.1016/S0003-4975(98)00444-5)

Fig 3 Histologic features show the neointima formation (A) and migration of smooth muscle cells (arrow) (B) into the neointima of nonphotooxided saphenous vein after culture for 21 days. Neointima (between arrows, luminal to the internal elastic lamina) is lightly stained (A). Neointima is absent above the internal elastic lamina (arrow) in a photooxidized saphenous vein cultured for 21 days (C), and smooth muscle cells are absent in the intima (D) of this vein segment. (A and C, elastin van Gieson; B and D, anti–alpha smooth muscle actin monoclonal antibody stains; ×100 before 32% reduction.) The Annals of Thoracic Surgery 1998 66, 449-454DOI: (10.1016/S0003-4975(98)00444-5)

Fig 4 Light photomicrographs show that the number of proliferating cell nuclear antigen-positive cells (arrow) is much less in the cultured photooxidized saphenous vein (A) than those in nonphotooxidized saphenous vein segments (B) cultured for 21 days. (Anti-proliferating cell nuclear antigen stain; ×100 before 32% reduction.) The Annals of Thoracic Surgery 1998 66, 449-454DOI: (10.1016/S0003-4975(98)00444-5)