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Intimal Hyperplasia and Expression of Transforming Growth Factor-β1 in Saphenous Veins and Internal Mammary Arteries Before Coronary Artery Surgery  Reinhard.

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Presentation on theme: "Intimal Hyperplasia and Expression of Transforming Growth Factor-β1 in Saphenous Veins and Internal Mammary Arteries Before Coronary Artery Surgery  Reinhard."— Presentation transcript:

1 Intimal Hyperplasia and Expression of Transforming Growth Factor-β1 in Saphenous Veins and Internal Mammary Arteries Before Coronary Artery Surgery  Reinhard Friedl, MD, Jun Li, MD, Bernd Schumacher, MD, Hartmut Hanke, MD, Johannes Waltenberger, MD, Andreas Hannekum, MD, Sylvia Stracke, MD  The Annals of Thoracic Surgery  Volume 78, Issue 4, Pages (October 2004) DOI: /j.athoracsur

2 Fig 1 (A) Human saphenous vein (HSV) with a circumferential intimal hyperplasia and an increased staining for transforming growth factor-β1 (TGF-β1) in the endothelial, intimal, and medial layer (original magnification ×5; inset ×20). (B) A normal native HSV without any tissue between the endothelium and the internal elastic membrane. Transforming growth factor-β1 staining in the medial layer is stronger than in the normal native internal mammary artery ([IMA] original magnification ×5; inset ×20). (C) Internal mammary artery with a focal intimal hyperplasia and an increased staining for TGF-β1 in the endothelial, intimal, and medial layer (original magnification ×5; inset ×20). (D) Normal IMA with no stromal or cellular tissue between the endothelium and the internal elastic membrane. Staining for TGF-β1 is weak (original magnification ×5; inset ×20). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )

3 Fig 2 The incidence of intimal hyperplasia (IH) was significantly higher in native human saphenous vein (HSV) compared with native internal mammary artery (IMA). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )


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