Crystal-Induced Kidney Disease in 2 Kidney Transplant Recipients Ravi Parasuraman, MD, K.K. Venkat, MD  American Journal of Kidney Diseases  Volume 55, Issue 1, Pages 192-197 (January 2010) DOI: 10.1053/j.ajkd.2009.08.012 Copyright © 2009 National Kidney Foundation, Inc. Terms and Conditions

Figure 1 Kidney allograft biopsy specimen from patient 1. Hematoxylin and eosin stain shows intratubular crystal deposition with multifocal tubular injury and interstitial inflammation. American Journal of Kidney Diseases 2010 55, 192-197DOI: (10.1053/j.ajkd.2009.08.012) Copyright © 2009 National Kidney Foundation, Inc. Terms and Conditions

Figure 2 Characterization of crystals in the kidney allograft biopsy specimen from patient 1. (A) Hematoxylin and eosin stain shows intratubular crystal deposition with tubulitis. (B) Birefringent oxalate crystals are visible under polarized light. American Journal of Kidney Diseases 2010 55, 192-197DOI: (10.1053/j.ajkd.2009.08.012) Copyright © 2009 National Kidney Foundation, Inc. Terms and Conditions

Figure 3 Kidney allograft biopsy specimen from patient 2. (A) Hematoxylin and eosin stain shows extensive intratubular crystal deposition typical of calcium phosphate. (B) von Kossa stain for phosphates shows the extent of calcium phosphate crystal deposition. American Journal of Kidney Diseases 2010 55, 192-197DOI: (10.1053/j.ajkd.2009.08.012) Copyright © 2009 National Kidney Foundation, Inc. Terms and Conditions

Figure 4 Metabolic pathway of vitamin C (ascorbic acid). Source for structures: PubChem (pubchem.ncbi.nlm.nih.gov). American Journal of Kidney Diseases 2010 55, 192-197DOI: (10.1053/j.ajkd.2009.08.012) Copyright © 2009 National Kidney Foundation, Inc. Terms and Conditions