Akihiko Ohkado, MD, Hung Cao-Danh, PhD, K. Eric Sommers, MD, Pedro J

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Presentation transcript:

Evaluation of highly buffered low-calcium solution for long-term preservation of the heart Akihiko Ohkado, MD, Hung Cao-Danh, PhD, K.Eric Sommers, MD, Pedro J. del Nido, MD The Journal of Thoracic and Cardiovascular Surgery Volume 108, Issue 4, Pages 762-771 (October 1994) DOI: 10.5555/uri:pii:S0022522394703051 Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 1 Preliminary experiments. Tissue concentrations and release of the glycolytic end products lactate and alanine during ischemia. (*p < 0.05 for total production in the Krebs + histidine versus the Krebs + KCl treated hearts.) The Journal of Thoracic and Cardiovascular Surgery 1994 108, 762-771DOI: (10.5555/uri:pii:S0022522394703051) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 1 Preliminary experiments. Tissue concentrations and release of the glycolytic end products lactate and alanine during ischemia. (*p < 0.05 for total production in the Krebs + histidine versus the Krebs + KCl treated hearts.) The Journal of Thoracic and Cardiovascular Surgery 1994 108, 762-771DOI: (10.5555/uri:pii:S0022522394703051) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 2 Comparison experiments (buffered versus UW solution). Left ventricular diastolic pressure measured with an intracavitary balloon 30 minutes after reperfusion. The same balloon volume that generated a diastolic pressure of 8 ± 1 mm Hg before ischemia was used for the postischemic measurements. (*p < 0.05 versus the buffered solution group.) The Journal of Thoracic and Cardiovascular Surgery 1994 108, 762-771DOI: (10.5555/uri:pii:S0022522394703051) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 3 Comparison experiments (buffered versus UW solution). Left ventricular developed pressure after 30 minutes of reperfusion measured at the same balloon volume as before ischemia. The results are expressed as percent of preischemic developed pressure for each heart. (*p < 0.05 versus the buffered solution group.) The Journal of Thoracic and Cardiovascular Surgery 1994 108, 762-771DOI: (10.5555/uri:pii:S0022522394703051) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 4 Optimal ischemic temperature (buffered solution). Tissue ATP and phosphocreatine concentrations at the end of 16 hours of ischemia and after 30 minutes of reperfusion (expressed as percent of the preischemic concentration). (*p < 0.05 for 13° C versus 4° C ischemia group; #(p < 0.05 for 13° C versus 21° C ischemia group.) The Journal of Thoracic and Cardiovascular Surgery 1994 108, 762-771DOI: (10.5555/uri:pii:S0022522394703051) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 5 Maximal ischemic time (buffered solution). Left ventricular diastolic (left) and developed pressure (right) measured after 30 minutes of reperfusion after different ischemic times. All hearts received hourly infusions of buffered solution at 13° C. Intracavitary balloon volume during the reperfusion measurements was maintained the same as before ischemia. (*p < 0.05 versus the 16-hour ischemia group.) The Journal of Thoracic and Cardiovascular Surgery 1994 108, 762-771DOI: (10.5555/uri:pii:S0022522394703051) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 5 Maximal ischemic time (buffered solution). Left ventricular diastolic (left) and developed pressure (right) measured after 30 minutes of reperfusion after different ischemic times. All hearts received hourly infusions of buffered solution at 13° C. Intracavitary balloon volume during the reperfusion measurements was maintained the same as before ischemia. (*p < 0.05 versus the 16-hour ischemia group.) The Journal of Thoracic and Cardiovascular Surgery 1994 108, 762-771DOI: (10.5555/uri:pii:S0022522394703051) Copyright © 1994 Mosby, Inc. Terms and Conditions