High-Dose Iodine-131-Metaiodobenzylguanidine with Haploidentical Stem Cell Transplantation and Posttransplant Immunotherapy in Children with Relapsed/Refractory.

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Presentation transcript:

High-Dose Iodine-131-Metaiodobenzylguanidine with Haploidentical Stem Cell Transplantation and Posttransplant Immunotherapy in Children with Relapsed/Refractory Neuroblastoma Jacek Toporski, Michael Garkavij, Jan Tennvall, Ingrid Øra, Katarina Sjögreen Gleisner, Josefina H. Dykes, Stig Lenhoff, Gunnar Juliusson, Stefan Scheding, Dominik Turkiewicz, Albert N. Békássy Biology of Blood and Marrow Transplantation Volume 15, Issue 9, Pages 1077-1085 (September 2009) DOI: 10.1016/j.bbmt.2009.05.007 Copyright © 2009 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Posttransplant chimerism analysis, virus reactivation, time of DLIs, and outcomes. Abbreviations: UPN, unique patient number; CMV, cytomegalovirus reactivation; BKV, BK virus reactivation; AdV, adenovirus reactivation; aGVHD, acute graft-versus-host disease; ATG, antithymocyte globulin treatment; DLI, donor lymphocyte infusion; DoD, died of disease; A&W, alive and well; NB, neuroblastoma; BM, bone marrow; m, months after haplo-SCT. Biology of Blood and Marrow Transplantation 2009 15, 1077-1085DOI: (10.1016/j.bbmt.2009.05.007) Copyright © 2009 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Immunological recovery (median values). Biology of Blood and Marrow Transplantation 2009 15, 1077-1085DOI: (10.1016/j.bbmt.2009.05.007) Copyright © 2009 American Society for Blood and Marrow Transplantation Terms and Conditions