Factor H Mutations in Hemolytic Uremic Syndrome Cluster in Exons 18–20, a Domain Important for Host Cell Recognition Anna Richards, Mark R. Buddles,

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Factor H Mutations in Hemolytic Uremic Syndrome Cluster in Exons 18–20, a Domain Important for Host Cell Recognition Anna Richards, Mark R. Buddles, Rosemary L. Donne, Bernard S. Kaplan, Edwin Kirk, Michael C. Venning, Christian L. Tielemans, Judith A. Goodship, Timothy H.J. Goodship The American Journal of Human Genetics Volume 68, Issue 2, Pages 485-490 (February 2001) DOI: 10.1086/318203 Copyright © 2001 The American Society of Human Genetics Terms and Conditions

Figure 1 Comparison of CCP19 and 20 wild-type amino acid sequence with the predicted sequence in patient 1 with delA3559. The abnormal amino acids are highlighted. The vertical line indicates the boundary between CCP 19 and 20. The American Journal of Human Genetics 2001 68, 485-490DOI: (10.1086/318203) Copyright © 2001 The American Society of Human Genetics Terms and Conditions

Figure 2 Amino acid sequence of the last two carboxy terminal CCPs for human, mouse, and sand bass FH and for human FHR1, 2, 3, and 4. The degree of homology at the mutation sites for patients 2, 3, 4, and 5 are shown by highlighting. The American Journal of Human Genetics 2001 68, 485-490DOI: (10.1086/318203) Copyright © 2001 The American Society of Human Genetics Terms and Conditions