Purification of CD4+ T Cells for Adoptive Immunotherapy after Allogeneic Hematopoietic Stem Cell Transplantation Evgeny Klyuchnikov, Andreas Sputtek,

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Purification of CD4+ T Cells for Adoptive Immunotherapy after Allogeneic Hematopoietic Stem Cell Transplantation Evgeny Klyuchnikov, Andreas Sputtek, Olga Slesarchuk, Michael Lioznov, Thomas Stübig, Ulrike Bacher, Gitta Amtsfeld, Edeltraut Merle, Marie-Luise Reckhaus, Boris Fehse, Christine Wolschke, Raissa Adjallé, Francis Ayuk, Axel Zander, Nicolaus Kröger Biology of Blood and Marrow Transplantation Volume 17, Issue 3, Pages 374-383 (March 2011) DOI: 10.1016/j.bbmt.2010.07.003 Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Results of initial CD4+-selected cell infusions (DLIs, donor lymphocyte infusions; CML, chronic myelogenous leukemia in chronic phase; HSV, herpes simplex virus; MDS, myelodysplastic syndromes; CR, complete remission; mCR, complete molecular remission; PR, partial remission; CDC, complete donor chimerism; CI, clinical improvement; GVHD, graft-versus-host disease.) Biology of Blood and Marrow Transplantation 2011 17, 374-383DOI: (10.1016/j.bbmt.2010.07.003) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Outcomes for CD4+-cells recipients regarding the presence of concomitant drug therapy. (DLIs, donor lymphocyte infusions; MDS, myelodysplastic syndrome; CML, chronic myelogenous leukemia in chronic phase; HSV, herpes simplex virus; mCR, complete molecular remission; CI, clinical improvement; CDC, complete donor chimerism; GVHD, graft-versus-host disease.) Biology of Blood and Marrow Transplantation 2011 17, 374-383DOI: (10.1016/j.bbmt.2010.07.003) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 The incidence of disease-free survival (DFS) following the CD4+-selected infusions. Biology of Blood and Marrow Transplantation 2011 17, 374-383DOI: (10.1016/j.bbmt.2010.07.003) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions