Prognostic Impact of Margin Distance and Tumor Spread Through Air Spaces in Limited Resection for Primary Lung Cancer Kyohei Masai, MD, Hiroyuki Sakurai,

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Prognostic Impact of Margin Distance and Tumor Spread Through Air Spaces in Limited Resection for Primary Lung Cancer Kyohei Masai, MD, Hiroyuki Sakurai, MD, Aoi Sukeda, MD, Shigeki Suzuki, MD, Keisuke Asakura, MD, Kazuo Nakagawa, MD, Hisao Asamura, MD, Shun-ichi Watanabe, MD, Noriko Motoi, MD, PhD, Nobuyoshi Hiraoka, MD, PhD Journal of Thoracic Oncology Volume 12, Issue 12, Pages 1788-1797 (December 2017) DOI: 10.1016/j.jtho.2017.08.015 Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

Figure 1 Representative images of tumor spread through air spaces (STAS) in adenocarcinoma (A–D), squamous cell carcinoma (E and F), and small cell carcinoma (G and H). STAS was found as a single cell (B), small cell cluster (B and H), or large nests (D and H). STAS was located near (C and E) or far (A and G) from the edge of the tumor. The right column images (B, D, F, and H) are the high-power views of the boxed areas. The asterisk indicates at least one free alveolar space between the STAS and main tumor. (A and E) Hematoxylin and eosin stain. Scale bars: 0.2 mm (A and E), 0.05 mm (B, D, and H), 0.5 mm (C and G), and 0.1 mm (F). Journal of Thoracic Oncology 2017 12, 1788-1797DOI: (10.1016/j.jtho.2017.08.015) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

Figure 2 Relapse-free survival curves for local recurrence of patients undergoing limited resection for primary lung cancer according to margin distance (A and B) and tumor spread through air spaces (STAS) (C). Journal of Thoracic Oncology 2017 12, 1788-1797DOI: (10.1016/j.jtho.2017.08.015) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions