Preconditioning with cromakalim improves long-term myocardial preservation for heart transplantation Matthias Kirsch, MD, Christophe Baufreton, MD, PhD,

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Presentation transcript:

Preconditioning with cromakalim improves long-term myocardial preservation for heart transplantation Matthias Kirsch, MD, Christophe Baufreton, MD, PhD, Christine Fernandez, Séverine Brunet, MD, Fabien Pasteau, MS, Alain Astier, PhD, Daniel Y Loisance, MD The Annals of Thoracic Surgery Volume 66, Issue 2, Pages 417-424 (August 1998) DOI: 10.1016/S0003-4975(98)00357-9

Fig 1 Maximal negative rates of left ventricular pressure relaxation (−dP/dtmax.) after 6 hours’ cold storage and 60 minutes of blood reperfusion. Data are shown as the mean ± the standard error of the mean. (STH = St. Thomas’ Hospital solution; UW = University of Wisconsin solution; ∗p < 0.05, UW and STH versus Control; §p < 0.01, STH versus UW; #p = 0.01, Cromakalim versus STH.) The Annals of Thoracic Surgery 1998 66, 417-424DOI: (10.1016/S0003-4975(98)00357-9)

Fig 2 Time constant of left ventricular isovolumetric pressure decay (τ) after 6 hours’ cold storage and 60 minutes of blood reperfusion. Data are shown as the mean ± the standard error of the mean. (STH = St. Thomas’ Hospital solution; UW = University of Wisconsin solution; ∗p < 0.05, STH versus other groups.) The Annals of Thoracic Surgery 1998 66, 417-424DOI: (10.1016/S0003-4975(98)00357-9)

Fig 3 Left ventricular (LV) developed pressure as a function of LV volume after 6 hours’ cold storage and 60 minutes of blood reperfusion. Data are shown as the mean ± the standard error of the mean. (STH = St. Thomas’ Hospital solution; UW = University of Wisconsin solution; $p < 0.03, Cromakalim versus Control; #p < 0.05, UW versus Control; ∗p < 0.05, STH versus UW, Cromakalim, and Control.) The Annals of Thoracic Surgery 1998 66, 417-424DOI: (10.1016/S0003-4975(98)00357-9)

Fig 4 Maximal positive rates of left ventricular pressure development (+dP/dtmax.) after 6 hours’ cold storage and 60 minutes of blood reperfusion. Data are shown as the mean ± the standard error of the mean. (STH = St. Thomas’ Hospital solution; UW = University of Wisconsin solution; ∗p < 0.05, UW, STH, and Cromakalim versus Control; §p < 0.01, STH versus UW; #p = 0.01, Cromakalim versus STH.) The Annals of Thoracic Surgery 1998 66, 417-424DOI: (10.1016/S0003-4975(98)00357-9)

Fig 5 (A) Creatine kinase (CK) and (B) lactate dehydrogenase (LDH) release during 60 minutes of blood reperfusion. Data are shown as the mean ± the standard error of the mean. Areas under release curves for University of Wisconsin solution (UW) and control (CTRL) groups are significantly smaller than areas under release curves for St. Thomas’ Hospital solution (ST), Cromakalim (Crom) or potassium-channel opener (cromakalim), 30 μg/kg (PCO30), and glibenclamide (Glib) groups. The Annals of Thoracic Surgery 1998 66, 417-424DOI: (10.1016/S0003-4975(98)00357-9)