Methods Objectives Results Conclusions ما ترک سربگفتیم تا دردسر نباشد غیر از خیال جانان، در جان و سر نباشد Effect of mindfulness based stress reduction (MBSR) on success of ICSI/ IVF , treatment, infertility stress, psychological symptoms and quality of life in infertile women Narges Bagheri Lankarani1, Payam Amini1,  Saman Maroufizadeh1 and Aslezaker Maryam1 1. Department of Epidemiology and Reproductive Health ,Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine ,ACECR ,Tehran ,Iran using the covariates values and their estimated coefficients. Two different models were fitted; first the psychological responses were assessed by intervention, time and the interaction between time and intervention while in the second model the intervention and time variables were adjusted for education, number for abortions, type of infertility, marriage duration, infertility duration, age and cause of infertility. The statistical analysis was performed using SPSS Version 20.0 (Chicago, IL). A significance level of 0.05 was considered for the tests. relationship concern, rejection concern and need for parenthood concern reduced significantly in the intervention group. No difference was found regarding the distribution of number of abortion, cause of infertility, type of infertility and education status of the patients. Adjustment for independent variables such as education, number for abortions, type of infertility, marriage duration, infertility duration, age and cause of infertility did not affect the significance of intervention, time and their interaction on several all of the psychological variables. According to the results of adjusted estimations (Model 2), the GSI score increased in the control group (score change estimate=0.047) after the intervention while decreased in the intervention group (score change estimate= -0.279+0.047= -0.232). The PST score decreased in the control group and increased in the intervention group after the intervention (score change estimate= 13.451-11.785=1.666). The slope of decrease for PSDI score in the intervention group was higher in the intervention group (score change estimate= -0.168) compared to the control group (score change estimate= -0.426). The mean decrease of stress score after the intervention in the control group was -1.523 while in the intervention group was 7.176. After the intervention, the mean decrease score of depression was 3.608 (p=0.007). Similar to a=unadjusted results, the GEE showed that social (p=0.380) and sexual concern (p=0.505) is not influenced by the intervention. However, the model showed decrease in relationship, that sexual concern. In contrast, the mean rejection and need for parents concern in the intervention group was 3.451 (p=0.043), 8.824 (p<0.001, and 16.412 (p<0.001), respectively. Objectives This study aimed to examine the effectiveness of mindfulness based stress reduction on success of ICSI/ IVF treatment, infertility stress, psychological symptoms and quality of life in infertile women. The study examined the role of psychological variables and quality of life in predicting IVF/ICSI outcome.  Results The patients were randomly and equally divided in two groups of intervention and control. The majority of the patients were educated over diploma (84.6%), did not have abortion (70.8%), with female cause of infertility (40.8%), and primary type of infertility (83.1%). The mean (standard deviation) age, duration of infertility and duration of marriage 31.06 (5.72), 4.55 (3.85) and 7.39 (4.51) years respectively. The patients’ age (p=0.070), marriage (p=0.956) and infertility duration (p=0.817) did not differ significantly between the groups. The patients Global Severity Index )GSI( score was the same before the intervention (p=0.521) and it decreases after the intervention both in within and between groups comparisons (p<0.001). The Positive Symptom Total )PST( score in the intervention group was significantly higher than the control group after the intervention (<0.001). The Positive Symptom Distress Index (PSDI) score reduced after the intervention in both intervention and control groups and it was lower among patients in the intervention category (p<0.001). The stress, anxiety and depression decreased significantly in the intervention group in comparison to the control group after intervention. In contrast to social concern, other dimensions such as sexual concern, Methods In this prospective study, a total of 130 infertile women (referred to Royan Institute in Tehran) were studied during their first IVF treatment. All subjects completed questionnaires of demographic, Depression Anxiety and Stress Scale (DASS-21), BSI, FPI and Fertiqol. The data were analyzed using both adjusted and unadjusted approaches. In the unadjusted methods, Chi-square test was used to investigate any association between the study group and categorical variables. Independent samples and paired t-tests were utilized to assess the continuous variables mean difference between the groups and within the time, respectively. Since the data was collected in two different time points over the study duration, generalized estimating equation (GEE) approach was used to assess the adjusted effect of intervention and time on the psychological factors. This approach yields the possibility of prediction and presents a statistical formula (model) in which the mean response can be predicted Conclusions The present study suggests that MBSR is efficacious, both in reducing psychological distress and improving clinical pregnancy rates.