Terje K. Steigen, MD, Ellen Aasum, MS, Truls Myrmel, MD, PhDa, Terje S

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Presentation transcript:

Effects of fatty acids on myocardial calcium control during hypothermic perfusion Terje K. Steigen, MD, Ellen Aasum, MS, Truls Myrmel, MD, PhDa, Terje S. Larsen, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 107, Issue 1, Pages 233-241 (January 1994) DOI: 10.5555/uri:pii:S0022522394704767 Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 1 Perfusion protocol showing temperature profile, perfusion conditions, and duration of various stages of heart perfusions. Arrows indicate end points at which hearts were swiched to calcium-free buffer, that is, 3 minutes before they were frozen between Wollenberger clamps cooled to temperature of liquid nitrogen. The Journal of Thoracic and Cardiovascular Surgery 1994 107, 233-241DOI: (10.5555/uri:pii:S0022522394704767) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 2 Cardiac output in normothermic (37° C) working rat hearts before and after 40 minutes of hypothermic (10° C) perfusion. Two groups of rat hearts were studied: one group perfused with Krebs-Henseleit bicarbonate buffer containing 11.1 mmol/L glucose (open symbols) and another with buffer containing 11.1 mmol/L glucose plus 1.2 mmol/L albumin-bound palmitate (filled symbols). Cardiac output was calculated on basis of timed collections of AF and CF every 5 minutes. Symbols represent mean plus or minus standard error of eight to nine hearts in each group. #p < 0.025 versus prehypothermic value in same group; * p < 0.05 versus corresponding value in glucose-perfused hearts: WH, working-heart perfusion; L, Langendorff perfusion. The Journal of Thoracic and Cardiovascular Surgery 1994 107, 233-241DOI: (10.5555/uri:pii:S0022522394704767) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 3 Registrations of aortic pressure during first minutes after rewarming in glucose-perfused (A) and palmitate-perfused (B) hearts. Arrows indicate switch from hypothermic Langendorff perfusion to normothermic working heart perfusion. Note delayed recovery of aortic pressure in palmitate-perfused hearts. The Journal of Thoracic and Cardiovascular Surgery 1994 107, 233-241DOI: (10.5555/uri:pii:S0022522394704767) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 4 [Ca2+]total in glucose-perfused and fatty acid-perfused hearts at different end points throughout experimental period, as indicated along horizontal axis. Calcium content was determined on basis of uptake of 45Ca2+.Values represent mean plus or minus standard error of five to eight hearts. #p < 0.0125 versus prehypothermic value in same perfusion group; *p < 0.05 versus corresponding value in glucose group; WH, working-heart perfusion; L, Langendorff perfusion. The Journal of Thoracic and Cardiovascular Surgery 1994 107, 233-241DOI: (10.5555/uri:pii:S0022522394704767) Copyright © 1994 Mosby, Inc. Terms and Conditions