Volume 20, Issue 6, Pages (June 2012)

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Volume 20, Issue 6, Pages 1077-1078 (June 2012) The Challenge of Using Gene- or Cell-Based Therapies to Treat Lung Disease Ronald G Crystal Molecular Therapy Volume 20, Issue 6, Pages 1077-1078 (June 2012) DOI: 10.1038/mt.2012.91 Copyright © 2012 The American Society of Gene & Cell Therapy Terms and Conditions

Figure 1 Combining gene transfer and stem/progenitor cell therapy to safely regenerate functional lung. Although stem/progenitor cell technology holds great promise for lung regeneration, there is the risk that the cells, once transplanted, will go awry, resulting in disordered lung and, at worst, malignant transformation. One solution is to genetically modify the stem/progenitor cells with suicide genes that could be switched on, deleting the transplanted cells and their progeny. Molecular Therapy 2012 20, 1077-1078DOI: (10.1038/mt.2012.91) Copyright © 2012 The American Society of Gene & Cell Therapy Terms and Conditions