Volume 145, Issue 1, Pages (January 2014)

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Volume 145, Issue 1, Pages 167-172 (January 2014) A Patient With Progressive Dyspnea and Multiple Foci of Airspace Consolidation Keith E. Boundy, MD, Armando E. Fraire, MD, Paulo J. Oliveira, MD, FCCP CHEST Volume 145, Issue 1, Pages 167-172 (January 2014) DOI: 10.1378/chest.13-0122 Copyright © 2014 The American College of Chest Physicians Terms and Conditions

Figure 1 A, The patient’s initial chest radiograph displaying multiple foci of airspace consolidation. B, Subsequent radiograph displaying clear interval progression. C, High-resolution chest CT scan with IV contrast displays bilateral peribronchovascular consolidations with scattered areas of ground-glass attenuation. D, Foci of dense airspace consolidation in the lung bases and relative sparing of the periphery. CHEST 2014 145, 167-172DOI: (10.1378/chest.13-0122) Copyright © 2014 The American College of Chest Physicians Terms and Conditions

Figure 2 A, Fiber-optic bronchoscopy showing tracheal ulceration (arrows). B, Hematoxylin-and-eosin-stained section (original magnification × 100) displaying bronchial tissue with squamous metaplasia, atypical squamous epithelium, and evidence of cytopathic effect with prominent multinucleated giant cells (arrows). C, Positive (orange) immunohistochemical staining (original magnification × 100) for herpes simplex virus, particularly prominent within cell nuclei. CHEST 2014 145, 167-172DOI: (10.1378/chest.13-0122) Copyright © 2014 The American College of Chest Physicians Terms and Conditions