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Recurrent Fevers, Cough, and Pulmonary Opacities in a Middle-Aged Man

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1 Recurrent Fevers, Cough, and Pulmonary Opacities in a Middle-Aged Man
Philippe R. Bauer, MD, PhD, FCCP, Clive S. Zent, MD, Marie-Christine Aubry, MD, FCCP, Jay H. Ryu, MD, FCCP  CHEST  Volume 137, Issue 6, Pages (June 2010) DOI: /chest Copyright © 2010 The American College of Chest Physicians Terms and Conditions

2 Figure 1 Chest CT scan during the first episode showing diffuse centrilobular nodules highly suggestive of subacute hypersensitivity pneumonitis. CHEST  , DOI: ( /chest ) Copyright © 2010 The American College of Chest Physicians Terms and Conditions

3 Figure 2 Transbronchial lung biopsy specimen during the first episode. Photomicrograph shows intraalveolar plugs of proliferating fibroblasts in a myxoid background (hematoxylin and eosin stain; original magnification × 200). CHEST  , DOI: ( /chest ) Copyright © 2010 The American College of Chest Physicians Terms and Conditions

4 Figure 3 Chest radiograph during the second episode. Ill-defined hazy increased density in both bases is more pronounced on the left side, causing partial obscuration of the left hemidiaphragm. CHEST  , DOI: ( /chest ) Copyright © 2010 The American College of Chest Physicians Terms and Conditions

5 Figure 4 Chest CT scan during the second episode. Predominant pattern of randomly distributed (both centrilobular and subpleural) poorly defined nodular opacities (white arrows), more extensive than seen on the initial chest CT scan, with a noticeably different morphology and without evidence of air-space consolidation or ground glass attenuation. CHEST  , DOI: ( /chest ) Copyright © 2010 The American College of Chest Physicians Terms and Conditions

6 Figure 5 Chest radiograph during the second episode with worsening symptoms, showing increase in the diffuse nodular opacities throughout both lungs. CHEST  , DOI: ( /chest ) Copyright © 2010 The American College of Chest Physicians Terms and Conditions

7 Figure 6 Chest CT scan during the second episode with worsening symptoms. Progression of radiologic abnormalities to include diffuse, randomly distributed lung nodules, curvilinear subpleural consolidation and/or atelectasis involving the left base, and evidence of subtle increased peripheral/subpleural reticular densities in the posterior right lung base, suggesting the development of mild fibrosis. CHEST  , DOI: ( /chest ) Copyright © 2010 The American College of Chest Physicians Terms and Conditions

8 Figure 7 Transbronchial lung biopsy specimen during the second episode. Photomicrograph shows intraalveolar plugs of proliferating fibroblasts in a myxoid background, similar to the previous biopsy specimen (hematoxylin and eosin stain; original magnification × 200). CHEST  , DOI: ( /chest ) Copyright © 2010 The American College of Chest Physicians Terms and Conditions


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