Did a Single Amino Acid Change Make Ebola Virus More Virulent?

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Did a Single Amino Acid Change Make Ebola Virus More Virulent? Trevor Bedford, Harmit S. Malik Cell Volume 167, Issue 4, Pages 892-894 (November 2016) DOI: 10.1016/j.cell.2016.10.032 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Evolutionary Course of the 2013–2016 Ebola Epidemic A time-resolved phylogenetic tree showing the evolutionary relationships among 1,261 Ebola viruses sampled during the 2013–2016 West African epidemic is depicted. Viruses (circles) are colored according to geographic division within Guinea (green hues), Sierra Leone (blue hues), and Liberia (orange hues). Internal branches are colored based on phylogeographic reconstruction given sampled locations and evolutionary relationships. This reconstruction estimates that the glycoprotein (GP) 82 mutation occurred around February 2014 in the Guéckédou prefecture of Guinea but immediately spread to the Kailahun district of Sierra Leone and from there drove the majority of overall epidemic. This phylogenetic reconstruction is taken from the website http://www.nextstrain.org/ebola/ by Richard Neher and Trevor Bedford that has maintained a real-time view of Ebola evolution (subject to data availability) since June 2015. Cell 2016 167, 892-894DOI: (10.1016/j.cell.2016.10.032) Copyright © 2016 Elsevier Inc. Terms and Conditions