Dissonant Synapses Shall Be Punished

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Dissonant Synapses Shall Be Punished Vassilis Kehayas, Anthony Holtmaat Neuron Volume 87, Issue 2, Pages 245-247 (July 2015) DOI: 10.1016/j.neuron.2015.06.040 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Depression of Synapses that Are Asynchronous with Their Neighbors Schematic of three spontaneously active neurons (red) that bear synaptic connections with the same target neuron (blue). The synapses of neurons 1 and 2 are activated synchronously over a timescale of seconds, but they are out of sync with synapse 3. Within minutes after the asynchronous events, the success rate for responses of synapse 3 becomes suppressed. Only synapses that are asynchronous with their neighbors located within ∼12 μm are depressed. The activity rates of synapses 1 and 2 remain unaltered. The depression effect is presynaptic and locally mediated by proBDNF/p75NTR signaling. Neuron 2015 87, 245-247DOI: (10.1016/j.neuron.2015.06.040) Copyright © 2015 Elsevier Inc. Terms and Conditions