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Synapse-Specific Encoding of Fear Memory in the Amygdala

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1 Synapse-Specific Encoding of Fear Memory in the Amygdala
Stephen Maren  Neuron  Volume 95, Issue 5, Pages (August 2017) DOI: /j.neuron Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Figure 1 Input-Specific LTP in the Lateral Amygdala during Discriminative Fear Conditioning Prior to fear conditioning, sensory afferents carrying information concerning conditional stimuli (CS+, CS−) from the auditory cortex (ACx) and medial geniculate nucleus (MGN) converge on principal neurons in the lateral amygdala (LA). During conditioning, coincident pre- and post-synaptic activity (red, active synapses and post-synaptic neurons) leads to input-specific long-term potentiation (LTP) at auditory afferents carrying CS+, but not CS−, information. Potentiated CS+ synapses (blue) allow the formerly innocuous CS to drive fear responses by depolarizing LA principal neurons. Neuron  , DOI: ( /j.neuron ) Copyright © 2017 Elsevier Inc. Terms and Conditions

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