Regulation Contact Inhibition Signals cells to stop dividing

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Presentation transcript:

Regulation Contact Inhibition Signals cells to stop dividing Proteins on cells Proteins from other organs Environmental conditions (availability of nutrients)

Checkpoints Feedback signals at key checkpoints delay or stop next phase of cycle G1 (Cells not healthy, too small, or conditions unsuitable for division) G2 (Recognize mistakes in DNA, or cell still too small) M [Metaphase] (Chromosomes not properly aligned to spindle fibers)

Cancer Uncontrolled cell division (Responds improperly or not at all) Form tumors – mass of cells Benign (Localized) Malignant (Metastasis)

Cancer Treatment- Surgery Chemotherapy Radiation

Cancer Prevention Avoidance UV radiation – cause skin cancer Chemicals- nicotine causes lung, trachea, mouth cancer

Assessment Checkpoints in cell cycle: A. signal cell death. B. maintain the homeostatic environment of cells interior. C. check that cell division occurs when cell is of suitable size and has met necessary internal conditions. D. limit the occurrence of cancer cell development to only 1% of cell reproduction events.