The role of mitochondrial activity in female fertility and assisted reproductive technologies: overview and current insights Gustavo Nardini Cecchino,

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The role of mitochondrial activity in female fertility and assisted reproductive technologies: overview and current insights Gustavo Nardini Cecchino, Emre Seli, Eduardo Leme Alves da Motta, Juan Antonio García-Velasco Reproductive BioMedicine Online Volume 36, Issue 6, Pages 686-697 (June 2018) DOI: 10.1016/j.rbmo.2018.02.007 Copyright © 2018 Reproductive Healthcare Ltd. Terms and Conditions

Figure 1 Electron transport chain (ETC) in the inner mitochondrial membrane. Reactions in complexes I, III and IV result in a stream of protons into the mitochondrial intermembrane space. In complex V, the energy generated by the mobilization of protons back into the mitochondrial matrix results in ATP synthesis by phosphorylation. NADH: nicotinamide adenine dinucleotide hydride, NAD+: nicotinamide adenine dinucleotide, CoQ10: coenzyme Q10, FADH2: flavin adenine dinucleotide hydride, FAD: flavin adenine dinucleotide, Cytc: cytochrome c, ADP: adenosine diphosphate; ATP: adenosine triphosphate. Reproductive BioMedicine Online 2018 36, 686-697DOI: (10.1016/j.rbmo.2018.02.007) Copyright © 2018 Reproductive Healthcare Ltd. Terms and Conditions

Figure 2 Oxidative stress-related factors and pathologies with a negative impact on female reproductive processes and assisted reproductive technology (ART) outcomes. Technical issues are well documented with the laboratory manipulation of gametes and embryos. There is increasing evidence that lifestyle habits and specific pathologies that generate oxidative damage also affect the female reproductive system and, ultimately, the success of ART. Reproductive BioMedicine Online 2018 36, 686-697DOI: (10.1016/j.rbmo.2018.02.007) Copyright © 2018 Reproductive Healthcare Ltd. Terms and Conditions