From cellular senescence to regeneration: A quest for the holy grail for the next generation of surgeons? Igor E. Konstantinov, MD, PhD, FRACS, Xin Tao.

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Presentation transcript:

From cellular senescence to regeneration: A quest for the holy grail for the next generation of surgeons? Igor E. Konstantinov, MD, PhD, FRACS, Xin Tao Ye, MD, Tyson A. Fricke, MBBS, BMedSci The Journal of Thoracic and Cardiovascular Surgery Volume 154, Issue 3, Pages 953-954 (September 2017) DOI: 10.1016/j.jtcvs.2017.05.036 Copyright © 2017 Terms and Conditions

Figure 1 Accumulation of senescent, senescence-associated β-galactosidase–positive, cells appears to play a key role in the initiation of regeneration process. A, In salamanders, senescent cells are efficiently eliminated via macrophage-dependent immune clearance, with complete regeneration of the damaged limb or organ. B, In humans, accumulation of senescent cells after myocardial infarction or pericarditis may result in scar formation and constrictive pericarditis. Improving the immune clearance of senescent cells may result in regeneration of the damaged tissue. SA-β-GAL, Senescence-associated β-galactosidase. The Journal of Thoracic and Cardiovascular Surgery 2017 154, 953-954DOI: (10.1016/j.jtcvs.2017.05.036) Copyright © 2017 Terms and Conditions

Accumulation of senescent, senescence-associated β-galactosidase–positive, cells appears to play a key role in the initiation of regeneration processes. Improving immune clearance of senescent cells may result in regeneration of the damaged tissue. The Journal of Thoracic and Cardiovascular Surgery 2017 154, 953-954DOI: (10.1016/j.jtcvs.2017.05.036) Copyright © 2017 Terms and Conditions